DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and LPO

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_006142.1	Gene:	LPO / 4025	HGNCID:	6678	Length:	712	Species:	Homo sapiens

Alignment Length:	723	Identity:	225/723 - (31%)
Similarity:	321/723 - (44%)	Gaps:	128/723 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 INAAYLDARKRIHVAQPKSDWKPEELATVGELLLDISIQLART-----YGLSYEEIEKGL----- 127
            :|.|:||:|.|:..|.      ..|..|..:|...:.....||     .|..:||..|.|
Human    45 VNKAFLDSRTRLKTAM------SSETPTSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKAS 103

  Fly   128 ------PTIDTSKTLIREVCPPFFAGVECRP-GKYRRFDGLCNNIEHPTWGAANAPFQRLIGPLY 185
                  |::|.:...:...|......|.|.| ..||...|.|||...|..||||....|.:...|
Human   104 LTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEY 168

  Fly   186 SDGIN-----APRISVTGRDLPFSRVVSRTM---HPDDGFHDHAGTVMVIAWGQFMDHDFTLTGT 242
            .||::     .|..:..|..||.:|.||..:   ..::|..|...:::.:.|||.:|||....
Human   169 EDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFA-- 231

  Fly   243 PLDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDYFYRLF---------NVKCIDFVR-GFPSPR 297
               |.......|..|       ..|:|..|..|:.|..:|         ..||:.|.| ||..|.
Human   232 ---PDTELGSSEYSK-------AQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPT 286

  Fly   298 PGCKLGSRQQFNTLTGVIDANTVYGVKESFARKLR--TGYGGLMRMNPVFQEYGLKDLLPLKLDI 360
            |..|..:|:|.|.||..:||:.||..:.|.|.:||  :...|||.:|....::|| ..||.....
Human   287 PPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGL-PYLPYDSKK 350

  Fly   361 PDEGCTRPNKS--MYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEAR 423
            |.. |...|.:  :.||..|:.|.:|.::|...|||..|||||||..|.::|..||.|.|:||||
Human   351 PSP-CEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEAR 414

  Fly   424 RINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYW----DGYDSTVNPGIIDSFAGAAFRFG 484
            :|..|.||.:||.::||||||..        :||   |    .||..:|:|.|.:.|. .|||||
Human   415 KILGAFVQIITFRDYLPILLGDH--------MQK---WIPPYQGYSESVDPRISNVFT-FAFRFG 467

  Fly   485 HSLLPTAVER-------WSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVAQAMDDS- 541
            |..:|:::.|       |....:.    .|..|....:.:.:.|.:|....||:.:.::.|..:
Human   468 HLEVPSSMFRLDENYQPWGPEPEL----PLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNK 528

  Fly   542 -ITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPNETV 605
             :|.|:.|.||:......|.||.:.|.||.|:.|.|||..:|.||.|....|.:|:      .||
Human   529 MMTGELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEEL------NTV 587

  Fly   606 LR-----------YGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYE 659
            |:           ||:    |.:||:|.|.::|..:....:||..||::..|...:|.|||||:|
Human   588 LKSKMLAKKLLGLYGT----PDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWE 648

  Fly   660 LPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDT------VQIYPMVLPDHEINPRVPCKSGIIP 718
               .|..||.||...::|...|||:||||.:...      ...||....|        |.:  |.
Human   649 ---NPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVD--------CSA--ID 700

  Fly   719 SIDLTKWA 726
            .:||:.||
Human   701 KLDLSPWA 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	193/582 (33%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	142/409 (35%)
LPO	NP_006142.1	An_peroxidase	138..674	CDD:281139	191/578 (33%)
LPO	NP_006142.1	myeloperoxidase_like	283..694	CDD:188656	150/441 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750