DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and Lar

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster

Alignment Length:	843	Identity:	149/843 - (17%)
Similarity:	245/843 - (29%)	Gaps:	352/843 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 YNVNLFRGTLNPYNNGPGTCITYDAINAAYLDARKRIHVAQPKSDWKPEELATV-GELLLDISIQ 111
            ||||: ....:.|:..|.|.||...            .:|.|:...||:....| ||.:|.|..|
  Fly  1183 YNVNV-SAIPSDYSYRPPTKITVTT------------QMAAPQPMVKPDFYGVVNGEEILVILPQ 1234

  Fly   112 LARTYG-LSYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRPGKYRRFDGLCNNIEHPTWGAANA 175
            .:..|| :|:..    |..:...|:.:.:: |..|...:..||:        |..|.|     ||
  Fly  1235 ASEEYGPISHYY----LVVVPEDKSNLHKI-PDQFLTDDLLPGR--------NKPERP-----NA 1281

  Fly   176 PF------QRLIGPLYSDGINAPRISVTGRDL-------------------------PFSRVVS- 208
            |:      ||.|...:..|......:.|.|.|                         |||..:|
  Fly  1282 PYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSL 1346

  Fly   209 ---------RTMHPDDGFHDHAGTVMVIAWGQFMDHDFTLTGTPLDP---INRN--DPE------ 253
                     |...||..            |             |.:|   :|||  :||
  Fly  1347 DMREAPPGERPHRPDPN------------W-------------PAEPEVSVNRNKDEPEILWVVL 1386

  Fly   254 --------------ECC--KRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDFVRGFPSPRPGCKL 302
                          ..|  ||    :...|   :.||.....|  .:...|...| |:|.....:
  Fly  1387 PLMVSTFIVSTALIVLCVVKR----RRQPC---KTPDQAAVTR--PLMAADLGAG-PTPSDPVDM 1441

  Fly   303 GSRQQFNTLTGVID---------ANTVYGVKESFARKLRTGYGGLMRMNPVFQEYGLKDLLPLKL 358
             .|..|.| .|:|.         ||.:..:|.:..:|..             |||...:
  Fly  1442 -RRLNFQT-PGMISHPPIPISEFANHIERLKSNDNQKFS-------------QEYESIE------ 1485

  Fly   359 DIPDEGCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEAR 423
              |.:..|..|.::                         |||:.....|.:..:        :..
  Fly  1486 --PGQQFTWDNSNL-------------------------EHNKSKNRYANVTAY--------DHS 1515

  Fly   424 RINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYD------STVNPGIIDSFAGAAFR 482
            |:.:..|:.|..::::                 ...|.|||.      :|..|
  Fly  1516 RVQLPAVEGVVGSDYI-----------------NANYCDGYRKHNAYVATQGP------------ 1551

  Fly   483 FGHSLLPTAVERWS-----KAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVAQAMDDSI 542
                |..|.|:.|.     |....:...||.:..|...|.|......|.:..:...:.:
  Fly  1552 ----LQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITE------ 1606

  Fly   543 TQEVTNHLFK-----KEGARFGMDLVSFNMQRGREFGIPG----YMEFRKFC------------- 585
            |||:..:..:     ::|.....::.........:.|:|.    :::|.:.|
  Fly  1607 TQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIV 1671

  Fly   586 ----GLPTSNTW---DEMYGSMPNETVLR-YGS------------------IFEHPADIDLWSGG 624
                |:..:..:   |.|...|.:|.::. ||.                  ||.|.|.::....|
  Fly  1672 HCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICG 1736

  Fly   625 VSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTD 689
            |:|  :|...|......::.|:              |.:..|.     .|:...|||.:..|::.
  Fly  1737 VTE--VPARNLHTHLQKLLITE--------------PGETISG-----MEVEFKKLSNVKMDSSK 1780

  Fly   690 LIDTVQIYPMVLPDHEINPRVPCKS------GIIP----SIDLTKWADFGGHGVDPSLYNYIN 742
            .               :...:||..      .|:|    .:.||..     ||::.|  :|:|
  Fly  1781 F---------------VTANLPCNKHKNRLVHILPYESSRVYLTPI-----HGIEGS--DYVN 1821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	110/672 (16%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	70/449 (16%)
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470	5/15 (33%)
		PTPc	1476..1731	CDD:214550	50/347 (14%)
		PTPc	1503..1731	CDD:238006	40/274 (15%)
		PTPc	1763..2022	CDD:214550	16/86 (19%)
		PTPc	1791..2022	CDD:238006	9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900