DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and Duox

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	177/680 - (26%)
Similarity:	279/680 - (41%)	Gaps:	178/680 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DARKRIHVAQPKSDWKPEEL---------ATVGELLLDISIQLARTYGLSYEEIEKGLPTIDTSK 134
            :::.|:    |:...|..:|         ||.|..||.:.|    :|||.
  Fly    12 ESKNRV----PRPGQKNRKLPKLRLHWPGATYGGALLLLLI----SYGLE--------------- 53

  Fly   135 TLIREVCPPFFAGVECRPGKY-----RRFDGLCNNIEHPTWGAANAPFQRLIGPLYSDGINAPRI 194
                      ...|.|....|     :|:||..||:.||.||:.::...|...|.||||:.|
  Fly    54 ----------LGSVHCYEKMYSQTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYA--- 105

  Fly   195 SVTGRDLPFSRVVSRT-MHPDDGFHDHAG-TVMVIAWGQFMDHDFTL---TGTPLDPINRNDPEE 254
             :.|.:.|.:|.:||. |...||...... |.::..:||.:.::..:   :|.|:: ::|.:.|:
  Fly   106 -MAGANRPSTRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEIVMASESGCPIE-MHRIEIEK 168

  Fly   255 CCKRPLHLKHPYCNEIRIPDDDY--FYRLFNVKCIDFVRGFPSPRPGCKLGSRQQFNTLTGVIDA 317
            |       ...|..|.|  .|.|  |:|    ...|...| .||.     ..|:|.|.:|..||.
  Fly   169 C-------DEMYDRECR--GDKYIPFHR----AAYDRDTG-QSPN-----APREQINQMTAWIDG 214

  Fly   318 NTVYGVKESFARKLRTGYGG--------------LMRM----NPVFQEYGLKDLLPLKLDIPDEG 364
            :.:|...|::...:|:.:.|              .||:    |||  ...:|.|.|.:|
  Fly   215 SFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVRNTMRVPLFNNPV--PSVMKMLSPERL------ 271

  Fly   365 CTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINIAI 429
                      |..|:.|.|:...:.....|..|.||.||..:.:::..|.||.::|.||...||.
  Fly   272 ----------FLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIAS 326

  Fly   430 VQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAVER 494
            :|:|...|:||..||..:..           ::||...::|||...|..|||||||:::|..:.|
  Fly   327 LQNVIVYEYLPAFLGTSLPP-----------YEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYR 380

  Fly   495 ----------------------WSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVAQA 537
                                  |..:..|.|...                ::|..|||.:|:::.
  Fly   381 RDGQCNFKETPMGYPAVRLCSTWWDSSGFFADTS----------------VEEVLMGLASQISER 429

  Fly   538 MDDSITQEVTNHLF-KKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDE----MY 597
            .|..:..:|.:.|| ..|..|  .||.:.|:.|||:.|:|.|...|:..||....||.:    ::
  Fly   430 EDPVLCSDVRDKLFGPMEFTR--RDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLF 492

  Fly   598 GSMPNETVLRYGSIFEHPADIDLWSGGVSEK-SLPGSMLGPTFACVIATQMSYLRRGDRFWYELP 661
            .:.|....:...:......|:|::.||:.|. ..||..    |..||..|...||..||||:|
  Fly   493 ETQPELLDMLKEAYDNKLDDVDVYVGGMLESYGQPGEF----FTAVIKEQFQRLRDADRFWFE-- 551

  Fly   662 NQPSS-FTPEQLQEIRKAKLSRLICDNTDL 690
            |:.:. ||||::.|:||..|..:|.::||:
  Fly   552 NERNGIFTPEEIAELRKITLWDIIVNSTDV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	162/595 (27%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	116/428 (27%)
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139	159/586 (27%)
		dual_peroxidase_like	72..625	CDD:188652	160/587 (27%)
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I2172
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910