DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and Mpo

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_006247157.1	Gene:	Mpo / 303413	RGDID:	1592081	Length:	718	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	253/780 - (32%)
Similarity:	372/780 - (47%)	Gaps:	156/780 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LQTAHGSDCALLLAGPGR-----------------SSVYDYNVNLFRGTLNPYNNGPGTCITY-- 70
            |||:.|:..||    ||.                 :..|.......:.:|...:..|...::|
  Rat    17 LQTSTGATPAL----PGEVANSVVLDCMEEAKRLVNKAYKERRESIKQSLRSGSASPMELLSYFK 77

  Fly    71 -------DAINAA-YLDARKRIHVA--------QPKSDW-KP---EELATVGEL-LLDISIQLAR 114
                   .|:.|| ||      |||        ||.  | :|   .::.|..:| ||.:|
  Rat    78 QPVAGTRTAVRAADYL------HVALDLLKRKLQPL--WPRPFNVTDVLTPAQLNLLSVS----- 129

  Fly   115 TYGLSYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRP-GKYRRFDGLCNNIEHPTWGAANAPFQ 178
             .|.:|:::                       ||.|.| .|||...|.|||...||.||:|..|.
  Rat   130 -SGCAYQDV-----------------------GVTCPPQDKYRTITGHCNNRRSPTLGASNRAFV 170

  Fly   179 RLIGPLYSDGIN-----APRISVTGRDLPFSRVVSRTM--HPDDGF-HDHAGTVMVIAWGQFMDH 235
            |.:...|.|||:     .|:::.:|..:|.:|.||..:  .|:|.. .|....:|.:.||||:||
  Rat   171 RWLPAEYEDGISLPFGWTPKVNRSGFKVPLARQVSNAIVRFPNDQLTKDQERALMFMQWGQFLDH 235

  Fly   236 DFTLTGTP------LDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDYFYRLFNVK-CIDFVRGF 293
            |.|||..|      |..:|   .|..|     |:...|..::||.:|  .|:.|.| ||.|.|..
  Rat   236 DITLTPEPATRFSFLTGLN---CETSC-----LQQQPCFPLKIPPND--PRIKNQKDCIPFFRSC 290

  Fly   294 PSPRPGCKLGSRQQFNTLTGVIDANTVYGVKESFARKLR--TGYGGLMRMNPVFQEYGLKDLLPL 356
            |: ..|..:..|.|.|.||..:||:.|||.::..||:||  |...||:.:|..||:.| :.|||.
  Rat   291 PA-CTGSNITIRNQINALTSFVDASGVYGSEDPLARRLRNLTNQLGLLAVNTRFQDNG-RALLPF 353

  Fly   357 KLDIPDEGCTRPNKS--MYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLF 419
            . .:.|:.|...|:|  :.||..|::|.:|...||.||||..||||||||.|.::|..|:.|.|:
  Rat   354 D-SLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTLFVREHNRLATELKRLNPRWNGEKLY 417

  Fly   420 QEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFRFG 484
            ||||:|..|:||.:|:.::||::||...|:|:   |.:   :..|:.:|:|.|.:.|.. |||:|
  Rat   418 QEARKIVGAMVQIITYRDYLPLVLGPAAMKKY---LPQ---YRSYNDSVDPRIANVFTN-AFRYG 475

  Fly   485 HSLLPTAVERWSKAHKFIASKRLSDLIRRPYDLYRA---GVLDEYFMGLM---------NQVAQA 537
            |:|:...:.|....::.........|.|..:..:|.   |.:|....|||         ||:|
  Rat   476 HTLIQPFMFRLDNQYRSTGPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIA-- 538

  Fly   538 MDDSITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPN 602
                 ..|:...|| ::..|.|:||.:.||||.|:.|:|||..:|:|||||..:|..|:...:.|
  Rat   539 -----VDEIRERLF-EQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPSTVGELGTVLKN 597

  Fly   603 -----ETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPN 662
                 :.:.:||:    |.:||:|.|||||...|...:|...||:|.||...||.|||||:|
  Rat   598 LELARKLMAQYGT----PNNIDIWMGGVSEPLEPNGRVGQLLACLIGTQFRKLRDGDRFWWE--- 655

  Fly   663 QPSSFTPEQLQEIRKAKLSRLICDNTDLIDTVQIYPMVLPDHEINPRVPCKSGIIPSIDLTKWAD 727
            .|..|:.:|.|.:....|.|:|||||. |.||....:.:.:......|.|.:  :|.::|..|.:
  Rat   656 NPGVFSKQQRQALATISLPRIICDNTG-ITTVSKNNIFMSNSHPRDFVSCNT--LPKLNLASWKE 717

Fly 728 727
Rat 718 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	209/572 (37%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	150/402 (37%)
Mpo	XP_006247157.1	myeloperoxidase_like	289..702	CDD:188656	158/438 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.900