DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and Ptgs2

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_058928.3	Gene:	Ptgs2 / 29527	RGDID:	620349	Length:	604	Species:	Rattus norvegicus

Alignment Length:	748	Identity:	145/748 - (19%)
Similarity:	241/748 - (32%)	Gaps:	252/748 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILRILLLSLA-AVAHA---------------------QYH-------QFGEQLQTAHGSDCALL 36
            |:.|.:||..| |::||                     ||.       .:||...|........|
  Rat     1 MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTTPEFLTRIKL 65

  Fly    37 LAGPGRSSVYDYNVNLFRGTLNPYNNGPGTCITYDAINAAYLDARKRIHVAQPKSDWKPEELATV 101
            |..|..::|: |.:..|:|..|..||.|   ...::|....|.:|..:..:.|
  Rat    66 LLKPTPNTVH-YILTHFKGVWNIVNNIP---FLRNSIMRYVLTSRSHLIDSPP------------ 114

  Fly   102 GELLLDISIQLARTYGLSYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRPGKYRRFDGLCNNIE 166
                         ||.:.|                                 .|:.::.. :|:.
  Rat   115 -------------TYNVHY---------------------------------GYKSWEAF-SNLS 132

  Fly   167 HPTWGAANAPFQRLIGPLYSDGINAPRISVTG-RDLPFSR-VVSRTMHPDDGFHDHAGTVMVIA- 228
            :         :.|.:.|: :|....| :.|.| ::||.|: |:.:.:...:...|..||.|:.|
  Rat   133 Y---------YTRALPPV-ADDCPTP-MGVKGNKELPDSKEVLEKVLLRREFIPDPQGTNMMFAF 186

  Fly   229 WGQFMDHDFTLTGTPLDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDFVRGF 293
            :.|...|.|..|.....|                                         .|.||
  Rat   187 FAQHFTHQFFKTDQKRGP-----------------------------------------GFTRG- 209

  Fly   294 PSPRPGCKLGSRQQFNTLTGVIDANTVYGVKESFARKLRTGYGGLMRMN--------PVFQEYGL 350
                    ||..         :|.|.|||.......|||....|.::..        |..::..:
  Rat   210 --------LGHG---------VDLNHVYGETLDRQHKLRLFQDGKLKYQVIGGEVYPPTVKDTQV 257

  Fly   351 KDLLP------LKLDIPDE--GCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALA 407
            ..:.|      |:..:..|  |.. |...||.                  |:..|||||:...|.
  Rat   258 DMIYPPHVPEHLRFAVGQEVFGLV-PGLMMYA------------------TIWLREHNRVCDILK 303

  Fly   408 QINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFG---LVLQKDGYWDGYDSTVN 469
            |.:..||||.|||.:|.|.|.....:...:::..|.|.....||.   |..|:..|.:...|..|
  Rat   304 QEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFN 368

  Fly   470 PGIIDSFAGAAFRFGHSLLPTAVERWSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQV 534
                      .....|.|||.......:.:.|   |:.         ||...:|.|:  ||.:.|
  Rat   369 ----------TLYHWHPLLPDTFNIEDQEYTF---KQF---------LYNNSILLEH--GLAHFV 409

  Fly   535 AQAMDDSITQEVTNHLFKKEGARFGMDLVS-FNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYG 598
                 :|.|:::...:.........:..|: .::.:.||.......|:||...|....:::|:.|
  Rat   410 -----ESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTG 469

  Fly   599 SMPNETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRG--------DR 655
            .  .|......:::.....::|:...:.||..|.::.|.|   ::.....:..:|        .:
  Rat   470 E--KEMAAELKALYHDIDAMELYPALLVEKPRPDAIFGET---MVELGAPFSLKGLMGNPICSPQ 529

  Fly   656 FWYELPNQPSSFTPE-QLQEIRKAKLSRLICDN 687
            :|     :||:|..| ..:.|..|.:..|||:|
  Rat   530 YW-----KPSTFGGEVGFRIINTASIQSLICNN 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	114/565 (20%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	86/410 (21%)
Ptgs2	NP_058928.3	EGF	21..53	CDD:278437	3/31 (10%)
Ptgs2	NP_058928.3	prostaglandin_endoperoxide_synthase	75..562	CDD:188648	128/674 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810