DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and Tpo

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_011242158.1	Gene:	Tpo / 22018	MGIID:	98813	Length:	915	Species:	Mus musculus

Alignment Length:	714	Identity:	233/714 - (32%)
Similarity:	345/714 - (48%)	Gaps:	117/714 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LDARKRIHVAQPKSDWK-PEELATVGEL-----LLDISIQLARTYGLSYEEIEKGLPTIDTSKTL 136
            |..|:.:..||..|.:| ||  :|.|.:     :::.|||:.:.....:.........:.|...|
Mouse    62 LKKREVLSPAQLLSFFKLPE--STSGAISRAAEIMETSIQVMKREQSQFSTDALSADILGTIANL 124

  Fly   137 IREVCPPFFAGVE----CRPGKYRRFDGLCNNIEHPTWGAANAPFQRLIGPLYSDGINAPR---- 193
              ..|.||.....    |...|||...|.|||.:||.|||:|....|.:.|:|.||.:.|:
Mouse   125 --SGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNP 187

  Fly   194 -ISVTGRDLPFSRVVSR--------TMHPDDGFHDHAGTVMVIAWGQFMDHDFTLTGTPLDPINR 249
             ....|..||..|.|:|        .:..||.:.|     .:..|||::|||..||
Mouse   188 NFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSD-----FLPVWGQYIDHDIALT--------- 238

  Fly   250 NDPEEC----------CKRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDFVRGFPSPRPGCKLGS 304
              |:..          |:.....::| |..|::|.:.    .....|:.|.|.    ...|..|.
Mouse   239 --PQSTSTAAFWGGVDCQLTCENQNP-CFPIQLPSNS----SGTTACLPFYRS----SAACGTGD 292

  Fly   305 -------------RQQFNTLTGVIDANTVYGVKESFARKLR--TGYGGLMRMNPVFQEYGLKDLL 354
                         |||.|.||..:||:||||......::||  :...||:|:|.:..:.| :..|
Mouse   293 QGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAG-RAYL 356

  Fly   355 PLKLD--IPDEGCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDET 417
            |....  .|:.|..|.|::. ||..|:.|.:|...|..:|||..|||||||:|...|||||...|
Mouse   357 PFATAACAPEPGTPRTNRTP-CFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANT 420

  Fly   418 LFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFR 482
            .:||||::..|:.|.:|..:::|.:||.:...::      .|.::||:.||||.:.:.|:.||||
Mouse   421 AYQEARKVVGALHQIITMRDYIPKILGPDAFRQY------VGPYEGYNPTVNPTVSNIFSTAAFR 479

  Fly   483 FGHSLLPTAVERWS---KAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVA--QAMDDSI 542
            |||:.:...|.|.:   :.|..:...:|.|:..||:.|.:.|.||....||:.:.|  |.....:
Mouse   480 FGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLM 544

  Fly   543 TQEVTNHLF--KKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPNETV 605
            .:|:|..||  ...|.   :||.|.|:||||:.|:|.|.|:|:||||....|..|:..::.|.::
Mouse   545 NEELTERLFVLSNVGT---LDLASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSM 606

  Fly   606 L-RYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQPSSFTP 669
            : :...:::|..:||:|.||::||.|||:..||.|||:|..||..||.|||||:|..|   .||.
Mouse   607 VNKIMDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTN---VFTD 668

  Fly   670 EQLQEIRKAKLSRLICDNTDL----IDTVQI--YPMVLPDHEINPRVPCKSGIIPSIDLTKWAD 727
            .|.||:.|..|.|:|||||.|    :|..:|  :|.   |.|     .|:.  |||:||..|.:
Mouse   669 AQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQ---DFE-----SCED--IPSMDLELWRE 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	201/588 (34%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	151/393 (38%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	204/609 (33%)
		CCP	730..783	CDD:153056
		EGF_CA	784..826	CDD:311536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.870