DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and pxn-1

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_505188.3	Gene:	pxn-1 / 191484	WormBaseID:	WBGene00004256	Length:	1285	Species:	Caenorhabditis elegans

Alignment Length:	688	Identity:	228/688 - (33%)
Similarity:	334/688 - (48%)	Gaps:	110/688 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DARKRIHVAQPKSDWKPEELATVGELLLDISIQLARTYGLSYEEIEKGL--------PTIDTSKT 135
            |.::....:.||   :..||:...| :.:.|::|.|      |.:||||        |...:.::
Worm   546 DLKRLFRFSTPK---QAVELSKARE-IYEESVRLVR------EHVEKGLILNVDELHPKNVSYES 600

  Fly   136 LIREVCPPFFAGVE-CRPG-------------KYRRFDGLCNNIEHPTWGAANAPFQRLIGPLYS 186
            ::.........|:. |..|             :||.|||.|||...|..|.:..|.:||:.|:|.
Worm   601 VLHVTHVQALMGLSGCHTGQYKNPCTDTCFHHRYRSFDGQCNNKNKPMTGVSLMPLRRLLKPVYE 665

  Fly   187 DGINAP------RISVTGRDLPFSRVVSRTMHPDDGFHDHAG-TVMVIAWGQFMDHDFTLTGTPL 244
            :|.|.|      |: ..|..||..|.|||.:...:....|:. :.||:.||||:|||.|.|.|.|
Worm   666 NGFNTPVGWEKGRL-YNGYPLPNVREVSRQLVATENITPHSKLSSMVMQWGQFVDHDLTHTVTAL 729

  Fly   245 DP--------INRN----DPEECCKRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDFVRGFPSPR 297
            ..        .||.    ||  |...||....|     |:......|     .||:|.|.    .
Worm   730 SRHSYATGAFCNRTCENLDP--CFNIPLSPNDP-----RVKSGSAKY-----PCIEFERS----A 778

  Fly   298 PGCKLGS----------RQQFNTLTGVIDANTVYGVKESFARKLRTGY--GGLMRMNPVFQEYGL 350
            ..|..|.          |:|.|.||..:||:.|||..|..|::||..|  .|::|.: :..|.|
Worm   779 AVCGSGETSLVFNRVTYREQMNALTSFLDASNVYGSNEVQAQELRDTYNNNGMLRFD-ITSEAG- 841

  Fly   351 KDLLPLKLDIPDEGCTR---PNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKH 412
            |:.||.:.| .:..|.|   ....:.||..|::|.||||.|...||:..|||||:|..|..:|.:
Worm   842 KEYLPFEKD-SNMDCRRNFSEENPIRCFLAGDLRANEQLALAATHTIFIREHNRIAKKLKSMNGN 905

  Fly   413 WDDETLFQEARRINIAIVQHVTFNEFLPILLGKEV-MEKFGLVLQKDGYWDGYDSTVNPGIIDSF 476
            ||.|.::.|.|:|..|::||:|:..::||:.|.:. |.||      .|.:.|||..|:..:.::|
Worm   906 WDGEIIYHETRKIVGAMMQHITYKHWMPIIFGGQAQMNKF------VGTYQGYDPDVDASVTNAF 964

  Fly   477 AGAAFRFGHSLLPTAVERWSKAHKFIASKR----LSDLIRRPYDLYRAGVLDEYFMGLM-NQVAQ 536
            |.|||||||:::..::.|  ..:.|:..|.    |......|..:...|.:|....||. :.:..
Worm   965 ATAAFRFGHTIINPSLFR--LGNDFMPIKEGHIALHKAFFTPELVLTQGGVDPLLRGLFASPLKH 1027

  Fly   537 AMDDS-ITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSM 600
            .|... :..|:...||.| |....:||...|:||.|:.|:|.|.|:||||.||....|::|.|.:
Worm  1028 PMPTQLLNMELIEKLFMK-GHEVSLDLAVMNIQRSRDHGLPSYTEYRKFCNLPVPVQWEDMKGYI 1091

  Fly   601 PNETVL-RYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQP 664
            .::.:: :...::..|.:||||.||:.|:.|...:.||||||:|..|...:|.|||||||   :.
Worm  1092 KDDMIIQKLRGLYGVPQNIDLWVGGIVEEKLENGLFGPTFACIIGEQFRKIRDGDRFWYE---KD 1153

  Fly   665 SSFTPEQLQEIRKAKLSRLICDNTDLIDTVQ----IYP 698
            ..||||||:||:|..|:||.|||.|.||.:|    :||
Worm  1154 GVFTPEQLREIKKITLARLFCDNGDNIDRIQKDVFMYP 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	205/578 (35%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	146/394 (37%)
pxn-1	NP_505188.3	LRRNT	23..51	CDD:279764
		leucine-rich repeat	35..53	CDD:275380
		LRR_8	52..112	CDD:290566
		LRR_4	53..93	CDD:289563
		leucine-rich repeat	54..77	CDD:275380
		LRR_4	77..120	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..117	CDD:275380
		LRR_8	123..182	CDD:290566
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		I-set	315..400	CDD:254352
		IGc2	328..392	CDD:197706
		IG_like	414..496	CDD:214653
		Ig	420..496	CDD:299845
		An_peroxidase	634..1181	CDD:281139	205/578 (35%)
		peroxidasin_like	757..1203	CDD:188658	163/464 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820