DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and K10B4.1

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_493669.2	Gene:	K10B4.1 / 187249	WormBaseID:	WBGene00019613	Length:	1294	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	236/789 - (29%)
Similarity:	383/789 - (48%)	Gaps:	137/789 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EQLQTAHGSDCALLLAGPGRSSVYDYNVNLFRGTLNPYNNGPGTCITYDAINAAYLDARKRIHVA 87
            :||:....:..:.::....::|:...:|  |:...| :.|.|..|      |::..        |
Worm   492 DQLEEVKKTSISAMMCRHQKTSIIQKDV--FKAADN-FQNIPIFC------NSSVF--------A 539

  Fly    88 QPK-SDW-------KPEELATV-GELLLDI------------------SIQLARTYGL------- 118
            :|. |.|       |.|:...: ||.:|::                  |:.| ::||.
Worm   540 KPDFSKWVETPEKHKNEQFDDILGECILEVFEARNRQRPATLQEGLHNSVAL-KSYGSMMLAKDE 603

  Fly   119 SYEEIEKGLPTIDTSKTLIR------------EVCPPF--FAGVECRP--------GKYRRFDGL 161
            :..|....|..::.:|.|::            .:...|  .:..:|.|        ..||.:.|.
Worm   604 AVNEANVSLILLEATKKLVKLKHIELDSIQSVNIGEDFGKKSDSQCNPKNLPCDSTNPYRSYTGW 668

  Fly   162 CNNIEHPTWGAANAPFQRLIGPLYSDGINAPRI-SVTGRDLPFSRVVSRTMHPDDGFHDHAGTV- 224
            |||:|.|:........:||:.|.|.|||:.||. ::||..||..||:|..:|       ||..:
Worm   669 CNNLETPSLANTFRELRRLLPPAYEDGIDLPRSKTITGSRLPSPRVISNMVH-------HAKKIE 726

  Fly   225 ------MVIAWGQFMDHDFTLTGTPLDPINRNDPEECCKR--PLHLKHPYCNEIRIPDDDYFYRL 281
                  .|:.:|||:|||  :|.:|:|. |.:.....|.|  ......|.|..|.:|.:|..:..
Worm   727 HVKYSHFVMEFGQFIDHD--ITHSPVDQ-NSDGTALNCSRCDSGRFVSPSCFPIPVPVNDVHFEP 788

  Fly   282 FNVKCIDFVRGFPSPRPGCKLGSRQQFNTLTGVIDANTVYGVKESFARKLRTGYGGLMRMNPVF- 345
            |:  |:.|||..|:.:   .||.|.|.|.::..:|.:.:||..:....:|||...|.|:.....
Worm   789 FS--CLSFVRSLPAQK---TLGYRNQMNQVSAYLDGSVMYGSTKCEGDRLRTFQDGKMKTTQTSR 848

  Fly   346 --QEYGLKDLLPLKLDIPDEGC-TRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALA 407
              :.||:  .|....:...:|| :.|:..  ||..|:.|.::|.:|..:|::..|||.|:.|.|.
Worm   849 APRHYGI--TLSQSDESEQDGCVSAPDAP--CFIAGDDRNSQQTLLIAVHSVFHREHERITTTLK 909

  Fly   408 QINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGI 472
            :||.:||||.::||.|::..|...|:.:||:|||::|:::::.:.|..::|||:|||:: .:..|
Worm   910 EINPNWDDEKIYQETRKLISAEFAHIVYNEYLPIIIGQKLIDDYDLRPRQDGYYDGYEN-CDASI 973

  Fly   473 IDSFAGAAFRFGHSLLPTAVERWSKAHK------FIASKRLSDLIRRPYDLYRAGVLDEYFMGLM 531
            :..||.||||||||.:..........|.      .:||..|:  :.:.||    ....|..:|.|
Worm   974 LQPFATAAFRFGHSTVTRFTPMQETVHDPATCVVDLASDFLN--MSKIYD----NEAVEQILGGM 1032

  Fly   532 NQVAQAMDDSITQE-VTNHLFKKEGAR-FGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWD 594
            :...|.|.|....: :.|.||...|.| .|:||:|.|:||||:.|||.|..:|.||||....::.
Worm  1033 HGKHQMMTDRFVDDAIRNFLFSDRGRRGTGLDLISINIQRGRDHGIPPYNHYRSFCGLSRLTSFY 1097

  Fly   595 EMYGSMPNETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYE 659
            .::..:..:.:...|.::|.|.||||::|.||||::||.::|||.||:||.|...|::.|||:||
Worm  1098 SIFSDINQDGLTAIGKVYESPDDIDLFTGIVSEKTIPGGIVGPTAACIIAEQFRRLKKCDRFYYE 1162

  Fly   660 LPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTVQIYPMV------LPDHEINPRVPCKSGIIP 718
            .....|.|:..||:|:||..:|.|||.||.:       |.:      :||...||.:.|  .:.|
Worm  1163 NGEDHSKFSASQLKEVRKTSMSALICANTKV-------PKISKDVFSVPDPFSNPLINC--DLYP 1218

  Fly   719 SIDLTKWAD 727
            .:||:||.|
Worm  1219 KLDLSKWRD 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	194/558 (35%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	139/393 (35%)
K10B4.1	NP_493669.2	An_peroxidase	93..509	CDD:281139	2/16 (13%)
		An_peroxidase_like	94..>321	CDD:265428
		An_peroxidase_like	224..508	CDD:265428	2/15 (13%)
		An_peroxidase	662..1191	CDD:281139	192/554 (35%)
		peroxinectin_like	807..1190	CDD:188655	139/393 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810