DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and pxn-2

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_509834.1	Gene:	pxn-2 / 181288	WormBaseID:	WBGene00004257	Length:	1328	Species:	Caenorhabditis elegans

Alignment Length:	811	Identity:	259/811 - (31%)
Similarity:	384/811 - (47%)	Gaps:	155/811 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DCALLLAG---PGRSSVY---DYNVNLFRGTLNPYNNGPGTCITYDAINAAYL------------ 78
            |...|..|   |.|::.|   |.|:.|....:..:::|..||...:::.:|..
Worm   475 DVVWLFEGIRIPRRNTRYTISDNNIELTIEKVTRHDSGVFTCQAVNSVGSAVATANLLVGAELTE 539

  Fly    79 ----------------DARKRIHVA------QPKSD--WKPEELATVGELLLDI----------- 108
                            :|::::..|      |.:.|  ..|.:|:.:.:..:::
Worm   540 KVDKLLDDSTIEKIAKEAKQKVEKALSSTKDQQRMDKIESPNDLSKLFKFAINLKKVDLGKAREI 604

  Fly   109 ---SIQLARTY---GLSYE--------EIEKGLPTIDTSKTLIREVCP--PFFAGVE--CRPGKY 155
               ||:|.:.:   ||::|        ..|..||.......:.:..|.  .|....|  |...||
Worm   605 YEESIRLVQMHIDNGLAFESAMISPNVSYEAVLPVSYVQTLMEKSGCQTGQFAESCEDHCFFSKY 669

  Fly   156 RRFDGLCNNIEHPTWGAANAPFQRLIGPLYSDGINAP-------RISVTGRDLPFSRVVSRTMHP 213
            |.:||.|||.|||.||.:...|.||:.|.|.:|.|.|       |.:  |.::|.:|.|||.:..
Worm   670 RSYDGQCNNHEHPWWGVSEMAFMRLLPPRYENGFNTPVGWEKGKRYN--GYEVPNARKVSRVLIG 732

  Fly   214 DDGF--HDHAGTVMVIAWGQFMDHDFTLTGTPLDPINRNDPEE--CCKRPLHLKHPYCNEIRIPD 274
            .|..  |.|. :.|.:.||||:|||.|||...|   .|:..:|  .|.|......| |..|::..
Worm   733 TDETTPHSHL-SAMTMQWGQFIDHDLTLTAPAL---TRHSYKEGAFCNRTCENADP-CFNIQLEA 792

  Fly   275 DD-----YFYRLFNVKCIDFVRGFPSPRPGCKLGS------------RQQFNTLTGVIDANTVYG 322
            ||     ..|:  ...|::|.|.      |...||            |.|.|.||..:||:.:||
Worm   793 DDPKLHTGLYQ--KHPCMEFERN------GAACGSGETSPIFQRVTYRDQLNLLTSYLDASGIYG 849

  Fly   323 VKESFARKLRTGYG--GLMRMNPVFQEYGLKDLLPLKLDIPDEGCTR------PNKSMYCFEGGE 379
            ..|..|.:||..|.  ||:|.:.|  ....|..:|.:.| .|..|.|      |.|   ||..|:
Worm   850 NSEEQALELRDLYSDHGLLRFDIV--SGANKPYMPFEKD-SDMDCRRNFSRENPIK---CFLAGD 908

  Fly   380 IRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLG 444
            :|.||||.|..|||:..|||||:|:.|.::|::||.||:|||.|::..|::||:|:|.:||.:||
Worm   909 VRANEQLGLMSMHTIFLREHNRIASRLLEVNENWDGETIFQETRKLIGAMLQHITYNAWLPKILG 973

  Fly   445 KEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAVERWSKAHKFIASKR--- 506
            |..   :..::   |.:.||:..|||.|.:.||.||.||.|:|:.|.:.|:.|  .|..:|:
Worm   974 KAT---YNTII---GEYKGYNPDVNPTIANEFATAALRFAHTLINTHLFRFDK--DFKETKQGHL 1030

  Fly   507 -LSDLIRRPYDLYRAGVLDEYFMGLMNQVAQ--AMDDSITQEVTNHLFKKEGARF---GMDLVSF 565
             |.:....|..|...|.:|....||.....:  ..|..:.:|:|..||.    ||   .:||.:.
Worm  1031 PLHNAFFAPERLVSEGGVDPLLRGLFAAPIKMPRPDQVLNKELTEKLFN----RFHEVALDLAAL 1091

  Fly   566 NMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPNETVL-RYGSIFEHPADIDLWSGGVSEKS 629
            |:||||:.|:|.:.|:||||.|....||.:|...:.|:||: :..|::....:||||.|||:||.
Worm  1092 NIQRGRDHGLPSWTEYRKFCNLTVPKTWSDMKNIVQNDTVISKLQSLYGVTENIDLWVGGVTEKR 1156

  Fly   630 LPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTV 694
            ...:::|||.||:||.|...||.|||||||   ....|:..||::|:|..||::||.|.|.||.:
Worm  1157 TADALMGPTLACIIADQFKRLRDGDRFWYE---NEEMFSKAQLRQIKKVTLSKIICTNGDDIDRI 1218

  Fly   695 QIYPMVLPDHEINPRVPCKSGIIPSIDLTKW 725
            |....|...:......||:|  :|.|:|..|
Worm  1219 QRDIFVYHGNSTQFYEPCES--LPEINLNMW 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	215/582 (37%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	155/399 (39%)
pxn-2	NP_509834.1	LRRNT	16..43	CDD:396168
		leucine-rich repeat	28..44	CDD:275380
		PRK15370	<35..>155	CDD:185268
		leucine-rich repeat	46..69	CDD:275378
		LRR_8	47..104	CDD:404697
		leucine-rich repeat	70..93	CDD:275378
		leucine-rich repeat	94..116	CDD:275378
		leucine-rich repeat	117..140	CDD:275378
		leucine-rich repeat	141..154	CDD:275378
		Ig	346..432	CDD:416386
		Ig strand B	369..373	CDD:409353
		Ig strand C	382..386	CDD:409353
		Ig strand E	405..410	CDD:409353
		Ig strand F	419..424	CDD:409353
		I-set	445..533	CDD:400151	13/57 (23%)
		Ig strand A'	453..457	CDD:409353
		Ig strand B	460..469	CDD:409353
		Ig strand C	475..480	CDD:409353	1/4 (25%)
		Ig strand C'	483..486	CDD:409353	0/2 (0%)
		Ig strand D	491..496	CDD:409353	1/4 (25%)
		Ig strand E	497..505	CDD:409353	2/7 (29%)
		Ig strand F	512..520	CDD:409353	3/7 (43%)
		Ig strand G	523..533	CDD:409353	1/9 (11%)
		peroxidasin_like	798..1238	CDD:188658	170/468 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820