DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and hpx-2

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_506432.1	Gene:	hpx-2 / 179880	WormBaseID:	WBGene00008627	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	731	Identity:	215/731 - (29%)
Similarity:	336/731 - (45%)	Gaps:	116/731 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 ITYDAINAAYLDAR-----------KRIHVA-QPKSDWKPEELATVGELLLDISIQLARTYGLSY 120
            |..||:..| ||:|           :.|.|: |..||.|..:.  .||:|.:.:..|.|.:||..
Worm    29 IVEDAVMRA-LDSRASENSESEQTSQHIIVSQQANSDSKSAQF--TGEVLEEATRILVREFGLEI 90

  Fly   121 ---------------EEIEKGLPTIDT----------------SKTLIREVC--PPFFAGVECR- 151
                           ||:.:...|..|                ||......|  ||    :.|.
Worm    91 LPAANEVIERWRNEEEELLQSSETTTTTEHPDPTRSKRSAIFRSKRQANRRCSSPP----INCNN 151

  Fly   152 --PGKYRRFDGLCNNIEHPTWGAANAPFQRLIGPL-YSDGINAPRI-SVTGRDLPFSRVVSRTMH 212
              ....|...|||||.::...|.:.:|.:|::|.. |:||:...|. ||.|.:||.:|::|..:|
Worm   152 RFHTSIRSITGLCNNRQNSDLGNSVSPLRRILGAASYADGLGRIRTRSVNGGELPSARLISNRIH 216

  Fly   213 PDDGFHDHAGTV----MVIAWGQFMDHDFTL-------TGTPLDPINRNDPEECCKRPLHLKHPY 266
            .|......:.::    |:|  |||:.||...       .|..||....|.|:..        .|.
Worm   217 DDRNNQVFSPSINHLHMII--GQFIAHDVVFMPSSVARDGGALDCSACNSPQRV--------SPN 271

  Fly   267 CNEIRIPDDDYFYRLFNVKCIDFVRGFPSPRPGCKLGSRQQFNTLTGVIDANTVYGVKESFARKL 331
            |..|.||.:|.:   ||..|:...|......   ..|.|.|....:..:|.:.|||..:..|..:
Worm   272 CAPITIPRNDPY---FNTPCMRLTRALNGQE---NFGVRSQIGQNSHFLDLSPVYGSADCEAETV 330

  Fly   332 RTGYGGLMRMNPVFQEYGLKDLLPLKLDIPDEGCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMA 396
            |:...|.|.   .|.:.|.  .||.: :..|..| :.:...:||..|:.|.:....|..:||::.
Worm   331 RSFQEGKML---TFDDLGY--TLPPQ-NANDSNC-QSSAPFHCFTCGDFRNSLHPALIPVHTILI 388

  Fly   397 REHNRLATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYW 461
            :||||||..:......::||.:||..|:|.|.:.||:.:||::|..|.:..:..|.|...::|..
Worm   389 KEHNRLAEQVRVARPRFNDEQIFQLVRKIMIGMWQHIVYNEYIPKYLPRRTIRNFALRPLRNGVH 453

  Fly   462 DGYDSTVNPGIIDSFAGAAFRFGHSL----LPTAVERWSKAHKFIASKRLSDLIRRPYDLY--RA 520
            .||.::|:|.|...|||||||||||.    .|...|....|..:    .|.:.|.....:|  |.
Worm   454 RGYSTSVDPSISAEFAGAAFRFGHSQSRFDFPRLTENGRPAGNY----DLGNDIFYADQMYLTRI 514

  Fly   521 GVLDEYFMGLMNQVAQAMDDSITQEVTNHLFKKEGAR-FGMDLVSFNMQRGREFGIPGYMEFRKF 584
            |..:....|::...|...|...:..:.|.:|:..|.. .|:||||.|:||||:.|:..|:::|:.
Worm   515 GGWEPVMNGMVRMPAMKSDRYFSFGIRNQMFEIRGRNGSGVDLVSINIQRGRDMGLFPYIQYRQL 579

  Fly   585 CGLPTSNTWDEMYGSMPNETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSY 649
            .||||..:::|:..:...|.:....:::..||||||:.|.:.|:.|.|..||||.:.:|..|...
Worm   580 VGLPTVTSFNELNTTFSQENIQALRNVYSDPADIDLYVGIMLEEPLSGGQLGPTASFMIGEQFRA 644

  Fly   650 LRRGDRFWYE-LPNQPSSFTPEQLQEIR-KAKLSRLICDNTDL---IDTVQIYPMVLPDHEINPR 709
            |:|||||:|| :.....:||.|::.|:| |..|:::||.|.|.   |:| .|:     ||. :.:
Worm   645 LKRGDRFFYESIAEGTDNFTQEEISELRNKTSLAKIICTNMDFAARINT-DIF-----DHR-SRQ 702

  Fly   710 VPCKSGIIPSIDLTKW 725
            |.|.|  :|.:|:.::
Worm   703 VACTS--LPQLDIDRF 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	175/561 (31%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	127/390 (33%)
hpx-2	NP_506432.1	An_peroxidase	158..696	CDD:376988	177/565 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49305
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.890