DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cysu and C46A5.4

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_501272.2	Gene:	C46A5.4 / 177558	WormBaseID:	WBGene00016700	Length:	1537	Species:	Caenorhabditis elegans

Alignment Length:	793	Identity:	262/793 - (33%)
Similarity:	386/793 - (48%)	Gaps:	102/793 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RILLLSLAAVAHAQYHQFGEQLQTAHGSDCALLLAGPGRSSVYD----------YNVNLFRGTLN 58
            ||:..:...|.|.|:|.|  .|...:| :|.|.....|...|:|          .::.:.:.|:.
Worm   707 RIICDNTDTVTHVQHHAF--SLPDDYG-NCPLSCNSTGIIQVFDPKAFKDEEKLTSLPITKETVE 768

  Fly    59 P-----------YNNGPGTCITYDAINAAYLDARKRIHVAQPKSDWKPEELATVGELLLDISIQL 112
            .           |..|.|..|:....:::.........:..||.:  ..::|....:|.:.:..|
Worm   769 KVIRLGLRQWQRYEEGEGRRISAQLSDSSPSALLSHALLMAPKKE--SIDIARTASVLREATNIL 831

  Fly   113 ARTYGLSYEE---------IEKGLPTIDTSKT-------LIREVCPPFFAGVECRP--------G 153
            ....||..:|         ::|.||.||....       |.|:..|.    .:|.|        .
Worm   832 ISGNGLDKDERLPDLDIGTLQKILPQIDVGSVIGNFTPFLARDPLPK----EQCLPEPLPCDHTS 892

  Fly   154 KYRRFDGLCNNIEHPTWGAANAPFQRLIGPLYSDGINAPRI-SVTGRDLPFSRVVSRTMHPD-DG 216
            |||.:.|.|||:::|.:|.|....:||:.|.|.||.:.||. ||.|.:||.:|.:|..:|.| ..
Worm   893 KYRTYSGWCNNLKNPKFGNAFTQMRRLLDPAYDDGFDTPRTRSVLGSELPSARKISNIVHSDAPK 957

  Fly   217 FHDHAGTVMVIAWGQFMDHDFTLTGTPLDPINRNDPEEC--CKRPLHLKHPYCNEIRIPDDDYFY 279
            ||... |.|::.:||.:|||  :..:|:....:|....|  |.....|. .:|..|:|..:|.|
Worm   958 FHVKF-THMLMQFGQILDHD--MMHSPISRGPKNTILNCSSCDSAQTLS-IHCFPIKIEANDPF- 1017

  Fly   280 RLFNVKCIDFVRGFPSP----RPGC-----------KLGSRQQFNTLTGVIDANTVYGVKESFAR 329
                         |||.    ||.|           .||.|.|.|.||..:||:|:||..:..|.
Worm  1018 -------------FPSKHSDGRPRCMPFARSLLAQVSLGFRNQLNQLTSFLDASTIYGSTQCEAN 1069

  Fly   330 KLRTGYGGLMRMNPVFQEYGL-KDLLPLKLDIPDEGCTRPNKSMYCFEGGEIRVNEQLVLTCMHT 393
            |||....|  ::|  |.:.|. |:.||......|......|:...||..|:.|.|||..||.:|.
Worm  1070 KLRLFSDG--KLN--FTDLGFNKEALPQGNQERDCRSVLQNRQRRCFVAGDERSNEQPGLTAIHN 1130

  Fly   394 LMAREHNRLATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKD 458
            :..|||||:|..|.|||..|.||.||||:||||||.:||:.:.|:||::||.:.|||:||:.|..
Worm  1131 IFLREHNRIARYLKQINNFWSDEKLFQESRRINIAQLQHIIYKEWLPVVLGCQNMEKWGLMPQTA 1195

  Fly   459 GYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAVERWSKAHKFIASK-RLSDLIRRPYDLY--RA 520
            ||::|||...:..|....:.:||||||||:.....|.:...:.:.:. .|::....|..:|  .:
Worm  1196 GYFEGYDDQCDATISQEMSTSAFRFGHSLIRGVFTRMNDNFQNMTNHVNLTETFSNPSPVYDKNS 1260

  Fly   521 GVLDEYFMGLMNQVAQAMDDSITQEVTNHLFKKEGARF-GMDLVSFNMQRGREFGIPGYMEFRKF 584
            |.::...|||:...:.|.|..|...|.||||.|.|... |:||.:.|:||||:.|:.||..:||.
Worm  1261 GHMESILMGLIGANSMAFDRHIVTAVRNHLFAKPGGPLTGLDLPAVNIQRGRDHGVQGYNAYRKH 1325

  Fly   585 CGLPTSNTWDEMYGSMPNETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSY 649
            |||..::.:.::...|.:|.|....:.:.|..||||:.|.:||....||::|||.||:|..||..
Worm  1326 CGLRKASAFSDLRDVMNSEAVTALETAYAHVDDIDLFPGIMSESPTRGSLVGPTLACLIGEQMQR 1390

  Fly   650 LRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTVQIYPMVLPDHEINPRVPCKS 714
            |::.|||:||..:....|||:||.|||||.|||:||||::....:|....::||...|..:.|..
Worm  1391 LKKCDRFYYETSDSMVRFTPDQLVEIRKASLSRIICDNSEYAANIQPNVFLMPDDLTNSPMTCSE 1455

  Fly   715 GIIPSIDLTKWAD 727
              :..|||.||.:
Worm  1456 --LSEIDLNKWVE 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	214/560 (38%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	159/386 (41%)
C46A5.4	NP_501272.2	An_peroxidase	182..717	CDD:281139	2/9 (22%)
		peroxinectin_like	334..712	CDD:188655	2/4 (50%)
		An_peroxidase	894..1429	CDD:281139	213/556 (38%)
		peroxinectin_like	1045..1428	CDD:188655	159/386 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810