DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and epx

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_021326443.1	Gene:	epx / 100331172	ZFINID:	ZDB-GENE-130425-2	Length:	828	Species:	Danio rerio

Alignment Length:	703	Identity:	227/703 - (32%)
Similarity:	331/703 - (47%)	Gaps:	128/703 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LDISIQLAR----TYG---------LSYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRPGKYRR 157
            ||.:::|.|    |:.         ||.|::|..|.....|..:.|.||..     :|...:||.
Zfish    34 LDNTVELIREMVYTHSMDKPDLSELLSAEDMETILQATGCSAEMKRPVCKS-----DCLSKRYRT 93

  Fly   158 FDGLCNNI----EHPTWGAANAPFQRLIGPLYSDGINAPR---------------ISVTGRDLPF 203
            ..|.|||.    |:|.|||||.|:.|.:.|.|.|...|||               :.:|.  :|.
Zfish    94 ITGHCNNSYFDRENPQWGAANTPYARWLSPQYEDPRGAPRGWSPQHTYHNHTLPPVRLTA--VPN 156

  Fly   204 SRVVSR----TMHPD---DGFHDHAGTVMVIAWGQFMDHDFTLTGTPLDPI-----NRNDPEECC 256
            .|.||:    |.:.:   ||...|    :::.|||::|||.||  ||..|.     .|.|    |
Zfish   157 VRRVSQEVLYTQNGNITLDGSLSH----LLVEWGQWIDHDLTL--TPQSPSTAAFRTRAD----C 211

  Fly   257 KRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDFVRGFPSPRPGCK--LGSRQQFNTLTGVIDANT 319
            .|......| |..|:||..|  .|.....|:.|.|..||    |.  ||.|:|.|.:|..:|::.
Zfish   212 TRTCSTDTP-CFPIQIPLSD--PRSHTQSCMAFFRSAPS----CSSPLGQREQLNAITAFVDSSM 269

  Fly   320 VYGVKESFARKLR--TGYGGLMRMNPVFQEYGLKDLLPL------KLDIP------DEGCTRP-- 368
            |||..::.|..||  :...||:.:|....:.|. |.:|.      :|| |      .:..|.|
Zfish   270 VYGSSDALALSLRNLSSPLGLLAVNQFHSDQGF-DFMPFLNRTQPQLD-PCGPRQHSDHTTAPQQ 332

  Fly   369 --NKSM----YCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINI 427
              |.||    :||:.|:.|.||.|.:..:|||..|||||||..|.:||.||..:||:||||:|..
Zfish   333 NNNISMGNASFCFQAGDSRANEHLGMIALHTLFLREHNRLAKELHRINPHWSPDTLYQEARKILG 397

  Fly   428 AIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAV 492
            |:.|.:|::.:||.:||:...:    :|..  .:.|||...:|.|.:.|:.|||||.|..:...|
Zfish   398 AVHQILTWDHYLPHVLGRSANQ----ILMP--AYKGYDPAADPSISNIFSTAAFRFAHVTVHPVV 456

  Fly   493 E------RWSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVA--QAMDDSITQEVTNH 549
            .      |.|.||..:.   |...:...:.:.:.|.:|....||:...|  |..|..:.:|:|..
Zfish   457 NRLGPDYRLSPAHPALP---LHHSLFASWRVVKEGGIDPVLRGLLVSPAKLQTADQMMVEELTER 518

  Fly   550 LFKKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPNETVLR-----YG 609
            ||:.:|. ..:||.:.|:||||:.|:.||..:|:.||||.......:.|.:.|..:.|     ||
Zfish   519 LFQAQGG-LPLDLAALNLQRGRDHGLQGYSVWRELCGLPAPVNESALSGILGNTALARKLLDLYG 582

  Fly   610 SIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQPSSFTPEQLQE 674
             :.|   :||:|.|.::|.:|||..:||..||:||.|...||.|||||::   ....|:..|...
Zfish   583 -VAE---NIDVWVGAIAEPALPGGRVGPLLACLIARQFRGLRDGDRFWWQ---NEGVFSSGQRDA 640

  Fly   675 IRKAKLSRLICDNTDLIDTVQIYPMVLPDHEINPRVPCKSGIIPSIDLTKWAD 727
            :|...|||:||:||. |..|.:.|..   :.:.|........|...:|:.|.:
Zfish   641 LRSTSLSRIICENTH-IQQVPLDPFT---NTMRPEELLSCSNIQLFNLSAWTE 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	205/604 (34%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	143/416 (34%)
epx	XP_021326443.1	An_peroxidase_like	111..689	CDD:326323	203/619 (33%)
		CCP	<711..747	CDD:153056
		EGF_CA	748..>775	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850