DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARVCF and vac8

DIOPT Version :9

Sequence 1:XP_006724306.1 Gene:ARVCF / 421 HGNCID:728 Length:1004 Species:Homo sapiens
Sequence 2:NP_595238.1 Gene:vac8 / 2541010 PomBaseID:SPBC354.14c Length:550 Species:Schizosaccharomyces pombe


Alignment Length:481 Identity:101/481 - (20%)
Similarity:184/481 - (38%) Gaps:134/481 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   352 EPRWRDPELPEVLAML-----RHPV-----DPVKA-NAAAYLQHLCFEN-------EGVKRRVRQ 398
            ||...|.|...|..:|     |:.|     :|::| ...||..:|..:.       |..::.||:
pombe    17 EPLLADREREAVADLLSFLEDRNEVNFYSEEPLRALTILAYSDNLDLQRSAALAFAEITEKDVRE 81

Human   399 L--RGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVR 461
            :  ..:..::.||..|.||::|.|..||.||:.  :.:|||.:....|:..|:|.:.:.. .||:
pombe    82 VDRETIEPVLFLLQSPDAEIQRAASVALGNLAV--NAENKALVVKLNGLDLLIRQMMSPH-VEVQ 143

Human   462 ELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCL 526
            ....|.:.||::.:..|..|              .|||........:|.:|..   |.:|.:|.|
pombe   144 CNAVGCITNLATLDENKSKI--------------AHSGALGPLTRLAKSKDIR---VQRNATGAL 191

Human   527 RNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADR 591
            .|: :...|.|::|... |.:..|:..|.|:    |||.:..  |...:.|:             
pombe   192 LNM-THSYENRQQLVSA-GTIPVLVSLLPSS----DTDVQYY--CTTSISNI------------- 235

Human   592 YQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDGEMDRNFDTLDLPKRTEAAKGFE 656
                       ||.:..|:|...|                                         
pombe   236 -----------AVDAVHRKRLAQS----------------------------------------- 248

Human   657 LLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELLQSE 721
               :|::||..:.|:..|......:||. ||:||::..     ..:..:.:...||.|:.||:|.
pombe   249 ---EPKLVRSLIQLMDTSSPKVQCQAAL-ALRNLASDE-----RYQIEIVQSNALPSLLRLLRSS 304

Human   722 TDKVVRAVAIALRNLSLDRRNKD-LIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVA-VLNTIH 784
            ...::.|....:||:|:...|:. :|.:..:..||..:          :|.|.:.:.. .::|:.
pombe   305 YLPLILASVACIRNISIHPLNESPIIDAGFLRPLVDLL----------SCTENEEIQCHAVSTLR 359

Human   785 EIVSDSLDNARSLLQARGVPALVALV 810
            .:.:.|..|.|::::|..:..|..|:
pombe   360 NLAASSERNKRAIIEANAIQKLRCLI 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARVCFXP_006724306.1 ARM 355..473 CDD:237987 36/137 (26%)
HEAT_2 360..462 CDD:290374 31/121 (26%)
armadillo repeat 360..385 CDD:293788 8/35 (23%)
armadillo repeat 393..429 CDD:293788 13/37 (35%)
armadillo repeat 436..471 CDD:293788 8/34 (24%)
ARM 437..579 CDD:237987 33/141 (23%)
armadillo repeat 478..529 CDD:293788 11/50 (22%)
ARM 656..756 CDD:237987 24/100 (24%)
armadillo repeat 656..692 CDD:293788 11/35 (31%)
armadillo repeat 702..736 CDD:293788 8/33 (24%)
armadillo repeat 743..788 CDD:293788 6/46 (13%)
armadillo repeat 794..826 CDD:293788 4/17 (24%)
vac8NP_595238.1 HEAT repeat 17..37 CDD:293787 6/19 (32%)
HEAT repeat 48..76 CDD:293787 6/27 (22%)
ARM 82..195 CDD:237987 34/133 (26%)
armadillo repeat 119..155 CDD:293788 10/36 (28%)
armadillo repeat 160..194 CDD:293788 11/50 (22%)
ARM 162..280 CDD:237987 39/211 (18%)
armadillo repeat 201..235 CDD:293788 10/40 (25%)
armadillo repeat 244..278 CDD:293788 11/78 (14%)
armadillo repeat 286..361 CDD:293788 17/84 (20%)
ARM 307..404 CDD:237987 17/89 (19%)
armadillo repeat 369..405 CDD:293788 4/17 (24%)
Arm 406..446 CDD:278915
armadillo repeat 410..444 CDD:293788
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2332
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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