DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and ctsd

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_571785.2	Gene:	ctsd / 65225	ZFINID:	ZDB-GENE-010131-8	Length:	398	Species:	Danio rerio

Alignment Length:	386	Identity:	158/386 - (40%)
Similarity:	225/386 - (58%)	Gaps:	25/386 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LIRIPMQFQASFMASRRQ-HRAGR-------SSLLAKYNVVGGQEVTSRNGGATETLDNRLNLEY 81
            ::|||::   .|...||. ..:||       ||...|||:    ...:.|....|||.|.|:.:|
Zfish    19 IVRIPLK---KFRTLRRTLSDSGRSLEELVSSSNSLKYNL----GFPASNDPTPETLKNYLDAQY 76

  Fly    82 AGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNASASSTFVPDGRRFSIAYGT 146
            .|.|.:|:|.|.|.::|||||:||||||..||...:||..||:||...|||:|.:|.:|:|.||:
Zfish    77 YGEIGLGTPVQTFTVVFDTGSSNLWVPSVHCSLTDIACLLHHKYNGGKSSTYVKNGTQFAIQYGS 141

  Fly   147 GSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGLGFRPIAELGIKPLFESMCD 211
            |||||.|:|||..||.:.|:.|.||.|..:||..|:...|.||:|:.:..||..|:.|:|:.|..
Zfish   142 GSLSGYLSQDTCTIGDIAVEKQIFGEAIKQPGVAFIAAKFDGILGMAYPRIAVDGVPPVFDMMMS 206

  Fly   212 QQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRIN 276
            |:.|::.||||||.||...:.|||||.||.|...::|...||.::...|||..:|.:.: |:.::
Zfish   207 QKKVEKNVFSFYLNRNPDTQPGGELLLGGTDPKYYTGDFNYVDISRQAYWQIHMDGMSI-GSGLS 270

  Fly   277 QNR---QAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCSEIDSLPEIVFIIGGQRFGL 338
            ..:   :||.||||||:..|..|...:...:|.:|....||:::|.::.:||.|.|.:||:.:.|
Zfish   271 LCKGGCEAIVDTGTSLITGPAAEVKALQKAIGAIPLMQGEYMVDCKKVPTLPTISFSLGGKVYSL 335

  Fly   339 QPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILGDVFIGRYYTAFDAGQRRIGFAPA 394
            ....|::. .:..|..||||.|..:|     ...|||||||||:|||.||....|:|||.|
Zfish   336 TGEQYILK-ESQGGHDICLSGFMGLDIPPPAGPLWILGDVFIGQYYTVFDRENNRVGFAKA 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	141/328 (43%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	138/321 (43%)
ctsd	NP_571785.2	A1_Propeptide	19..44	CDD:285240	8/27 (30%)
		Cathepsin_D2	70..394	CDD:133157	139/325 (43%)
		Asp	75..395	CDD:278455	138/321 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.790