Protein Alignment CG5863 and PGA3

DIOPT Version :9

• Sequence 1: NP_650623.1
• Gene: CG5863 / 42096
• FlyBaseID: FBgn0038507
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: NP_001073275.1
• Gene: PGA3 / 643834
• HGNCID: 8885
• Length: 388
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 153/398 - (38%)
• Similarity: 228/398 - (57%)
• Gaps: 26/398 - (6%)

  Fly    12 WILCL-FWAKCQGQLIRIPMQFQASFMASRR--QHRAGRSSLLAKYNVVGGQEVTSRNGGAT--- 70
            |:|.| ..|..:..:.::|:..:.|.   ||  ..|......|.|:|:...::...:....|
Human     3 WLLLLGLVALSECIMYKVPLIRKKSL---RRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVD 64

  Fly    71 -ETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNASASSTFV 134
             :.|:|.|::||.|.|.||:|.|.|.::|||||:||||||..||  |:||.:|:|:|...|||:.
Human    65 EQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCS--SLACTNHNRFNPEDSSTYQ 127

  Fly   135 PDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGLGFRPIAE 199
            ......||.|||||::|.|..|||.:|.:...||.||::..|||.......|.||:||.:..|:.
Human   128 STSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISS 192

  Fly   200 LGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFP 264
            .|..|:|:::.:|.||.:.:||.||  :..::.|..::|||:|.:.::|||.:||:|..||||..
Human   193 SGATPVFDNIWNQGLVSQDLFSVYL--SADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQIT 255

  Fly   265 LDVIEVAGTRI--NQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCSEIDSLPEI 327
            :|.|.:.|..|  .:..|||.|||||||..|......|.|.:|....|:.:.:::||.|.|||:|
Human   256 VDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI 320

  Fly   328 VFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILGDVFIGRYYTAFDAGQR 387
            ||.|.|.::.:.|..|::.:   :||  |:|.|..|:     .|.||||||||.:|:|.||....
Human   321 VFTINGVQYPVPPSAYILQS---EGS--CISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANN 380

  Fly   388 RIGFAPAA 395
            ::|.||.|
Human   381 QVGLAPVA 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	137/327 (42%)
		Asp	80..394	CDD:278455	135/320 (42%)
PGA3	NP_001073275.1	A1_Propeptide	17..45	CDD:285240	6/30 (20%)
		pepsin_A	66..386	CDD:133145	137/328 (42%)
		Asp	75..387	CDD:278455	135/320 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm8487
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.930