Protein Alignment CG5863 and REN

DIOPT Version :10

• Sequence 1: NP_650623.1
• Gene: CG5863 / 42096
• FlyBaseID: FBgn0038507
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: NP_000528.1
• Gene: REN / 5972
• HGNCID: 9958
• Length: 406
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 132/401 - (32%)
• Similarity: 203/401 - (50%)
• Gaps: 23/401 - (5%)

  Fly    12 W-ILCLFWAKCQGQLIRIPMQFQASF---MASRRQHRAGRSSLLAKYNVVGGQ---EVTSRNGGA 69
            | :|.|.|..|...|......|:..|   |.|.|:....|...:|:......|   .:|..|..:
Human    10 WGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTS 74

  Fly    70 TETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNASASSTFV 134
            :..|.|.::.:|.|.|.||:|.|.|.::|||||:|:||||::||....||.:|..::||.||::.
Human    75 SVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYK 139

  Fly   135 PDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGLGFRPIAE 199
            .:|...::.|.||::||.|:||.:.:|.:.| .|.||..|..|...|:...|.|:||:||...|.
Human   140 HNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAI 203

  Fly   200 LGIKPLFESMCDQQLVDECVFSFYLKRN--GSERKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQ 262
            ..:.|:|:::..|.::.|.|||||..|:  .|:..||:::.||.|...:.|:..|:.|...|.||
Human   204 GRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQ 268

  Fly   263 FPLDVIEVAGTRI--NQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNN--EYLLNCSEIDS 323
            ..:..:.|..:.:  .....|:.|||.|.::.....   |..|:..|.....  :|::.|:|..:
Human   269 IQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSS---IEKLMEALGAKKRLFDYVVKCNEGPT 330

  Fly   324 LPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILGDVFIGRYYTAFD 383
            ||:|.|.:||:.:.|...|||...:. ....:|..|...||     ...|.||..||.::||.||
Human   331 LPDISFHLGGKEYTLTSADYVFQESY-SSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFD 394

  Fly   384 AGQRRIGFAPA 394
            ....|||||.|
Human   395 RRNNRIGFALA 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	Asp	80..394	CDD:394983	113/324 (35%)
REN	NP_000528.1	A1_Propeptide	33..>51	CDD:462326	5/17 (29%)
		renin_like	78..405	CDD:133154	115/331 (35%)