Protein Alignment CG5863 and Bace2

DIOPT Version :9

• Sequence 1: NP_650623.1
• Gene: CG5863 / 42096
• FlyBaseID: FBgn0038507
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: NP_062390.3
• Gene: Bace2 / 56175
• MGIID: 1860440
• Length: 514
• Species: Mus musculus
• Alignment Length: 465
• Identity: 114/465 - (24%)
• Similarity: 185/465 - (39%)
• Gaps: 125/465 - (26%)

  Fly     9 LSLWILCLFWAKCQGQLIRIPMQFQASFMASRRQHRAGRSSLLAKYNVVGGQEVTSRNGGA---- 69
            |:.|:|....|..... ..:|:|     :|....|||.....|      |..|:...:|.|
Mouse    13 LAQWLLSAVPALAPAP-FTLPLQ-----VARATNHRASAVPGL------GTPELPRADGLALALE 65

  Fly    70 -----------TETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHH 123
                       .:.|.......|...:.||:|.|...:|.||||:|..|..|   |.|....:
Mouse    66 PVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGA---PHSYIDTY-- 125

  Fly   124 RYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNF-- 186
             :::.:|||:...|...::.|..||.:|.:.:|.|.|.:....:....:||     .|...||
Mouse   126 -FDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIAT-----IFESENFFL 184

  Fly   187 -----AGIVGLGFRPIAE--LGIKPLFESMCDQQLVDECVFSFY-----LKRNGSERKGGELLFG 239
                 .||:||.:..:|:  ..::..|:|:..|..:.: :||..     |...||...||.|:.|
Mouse   185 PGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPD-IFSMQMCGAGLPVAGSGTNGGSLVLG 248

  Fly   240 GVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIADTGTSLLAAPPREY- 297
            |::.:.:.|.:.|.|:....|:|..:..:|:.|..:|.:      .:||.|:||:||..|.:.:
Mouse   249 GIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSGTTLLRLPQKVFD 313

  Fly   298 ---------LIINSLLGGLPT-------SNNE-----------YLL--NCS---EIDSLPEIVF- 329
                     .:|.....|..|       :|:|           ||.  |.|   .|..||::..
Mouse   314 AVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQ 378

  Fly   330 -IIGG------QRFGLQPRDYVMSATNDDGSSICLSAFTLMDAEFWILGDVFIGRYYTAFDAGQR 387
             ::|.      .|||      :.|:||    ::.:.| |:|:.            :|..||..||
Mouse   379 PMMGAGFNYECYRFG------ISSSTN----ALVIGA-TVMEG------------FYVVFDRAQR 420

  Fly   388 RIGFA--PAA 395
            |:|||  |.|
Mouse   421 RVGFAVSPCA 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	95/381 (25%)
		Asp	80..394	CDD:278455	96/376 (26%)
Bace2	NP_062390.3	beta_secretase_like	85..446	CDD:133140	98/381 (26%)
		Asp	88..425	CDD:278455	94/371 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810