DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and pga4

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_002942158.1	Gene:	pga4 / 496914	XenbaseID:	XB-GENE-979768	Length:	384	Species:	Xenopus tropicalis

Alignment Length:	401	Identity:	162/401 - (40%)
Similarity:	223/401 - (55%)	Gaps:	27/401 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISLWLSLWILCLFWAKCQGQLIRIPMQFQASFMASRRQHRAGRSSLLA------KYNVVGGQEVT 63
            :.|.|.|.::.|  ::|   ::::|::...||     ::|..|..||.      .||.......|
Frog     1 MKLLLLLGLVVL--SEC---VVKVPLRKGESF-----RNRLQRLGLLGDYLKKYPYNPASKYFPT 55

  Fly    64 SRNGGATETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNAS 128
            .....| |.|.|.:::||.|.||||:|.|.|.::||||||||||||..||  |.||.:|:|:|..
Frog    56 LAQSSA-EVLQNYMDIEYYGTISIGTPPQEFTVIFDTGSANLWVPSVYCS--SSACTNHNRFNPQ 117

  Fly   129 ASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGLG 193
            .|:||.......||.|||||:||.|..||:.:|.:.:.||.||::..|||.....:.|.||:||.
Frog   118 QSTTFQATNTPVSIQYGTGSMSGFLGYDTLQVGNIKISNQMFGLSESEPGSFLYYSPFDGILGLA 182

  Fly   194 FRPIAELGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTHA 258
            |..||.....|:|::|..|.|:.:.:||.||..:|  :.|..:||||||.:.:||||.:||||..
Frog   183 FPSIASSQATPVFDNMWSQGLIPQNLFSVYLSSDG--QSGSYVLFGGVDTSYYSGSLNWVPLTAE 245

  Fly   259 GYWQFPLDVIEVAGTRI--NQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCSEI 321
            .|||..||.|.:.|..|  :|:.|||.||||||:..|......|...:|....||.:|::||:.|
Frog   246 TYWQIILDSISINGQVIACSQSCQAIVDTGTSLMTGPTTPIANIQYYIGASQDSNGQYVINCNNI 310

  Fly   322 DSLPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTL--MDAEFWILGDVFIGRYYTAFDA 384
            .::|.|||.|.|.::.|.|..||..  |..|.|....|.||  ...:.||||||||.:|:..||.
Frog   311 SNMPTIVFTINGVQYPLPPTAYVRQ--NQQGCSSGFQAMTLPTNSGDLWILGDVFIRQYFVVFDR 373

  Fly   385 GQRRIGFAPAA 395
            ....:..||.|
Frog   374 TNNYVAMAPVA 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	143/324 (44%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	141/317 (44%)
pga4	XP_002942158.1	A1_Propeptide	16..44	CDD:369623	7/32 (22%)
pga4	XP_002942158.1	pepsin_A	62..382	CDD:133145	143/325 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110