Protein Alignment CG5863 and bace2

DIOPT Version :10

• Sequence 1: NP_650623.1
• Gene: CG5863 / 42096
• FlyBaseID: FBgn0038507
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: XP_009289748.1
• Gene: bace2 / 449818
• ZFINID: ZDB-GENE-041010-68
• Length: 503
• Species: Danio rerio
• Alignment Length: 455
• Identity: 114/455 - (25%)
• Similarity: 180/455 - (39%)
• Gaps: 112/455 - (24%)

  Fly     7 LWLSLWILCLFWAKCQGQLIRIPMQ-FQASFMAS--------RRQHRAGRSSLLAKYNVVGGQEV 62
            |.|||    .||.  ...:.:||:. |...|.||        ::...|.:|          |..:
Zfish     7 LLLSL----TFWK--SHSVFKIPLNIFAGKFNASVQLDLRPLQKNEAAAKS----------GLSL 55

  Fly    63 TSRNGGATETLDNRLNLE------YAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHH 121
            .|...|....||...||:      |...:.||:|||..|:|.||||:|..|        :.|.|.
Zfish    56 ASDPAGIVNFLDMINNLKGDSGRGYYMQMIIGTPGQTLNILVDTGSSNFAV--------AAAAHP 112

  Fly   122 H--HRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAI-----GQLVVQNQTFGMATHE--- 176
            :  |.:|.:.|||:....|..::.|..|...|.|..|.:.|     |.:.:  ....:.|.|
Zfish   113 YITHYFNRALSSTYQSTERAVAVKYTQGEWEGELGTDLITIPEGPSGAITI--NIAAILTSEGFF 175

  Fly   177 -PGPTFVDTNFAGIVGLGFRPIA--ELGIKPLFESMCDQQLVDECVFSFYLKRNG------SERK 232
             ||     .|:.||:||.:..:|  :..::|.|.|:..|..:.: |||..:...|      .:..
Zfish   176 LPG-----INWQGILGLAYPLLARPDPSVEPFFNSVVRQTGIPD-VFSLQMCGAGVPASTTGDPA 234

  Fly   233 GGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRIN------QNRQAIADTGTSLLA 291
            ||.|:.|||:.|...|.:.|.|:....|:|..:..:||....:|      .:.:||.|:||:||.
Zfish   235 GGSLIMGGVEPTLHRGPIWYTPVLEEWYYQVEVLKLEVGDQNLNLDCKEYNSDKAIVDSGTTLLR 299

  Fly   292 APPREYLIINSLLGGLPTSNNEYLLNCSEIDS-----------------------LPEIVFIIGG 333
            .|...:           |:..:.::..|.||.                       .|::...:.|
Zfish   300 LPANVF-----------TAVVDTIMQTSLIDDFSAGFFDGTKLACWMRGESPWRFFPKVSIYLRG 353

  Fly   334 Q------RFGLQPRDYVMSATNDDGSSICLSAFTLMDAEFWILGDVFIGRYYTAFDAGQRRIGFA 392
            .      |..:.|:.|:...|:.||:..|........|...::|...:..:|..||..|:|:|||
Zfish   354 TNTSQSFRITILPQLYIQPVTDIDGTLDCFRFGISPSANGLVIGATVMEGFYVIFDRAQKRVGFA 418

  Fly   393  392
            Zfish   419  418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	Asp	80..394	CDD:394983	93/373 (25%)
bace2	XP_009289748.1	beta_secretase_like	77..439	CDD:133140	93/369 (25%)