DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and ctsd

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_988964.1	Gene:	ctsd / 394561	XenbaseID:	XB-GENE-5906945	Length:	398	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	162/404 - (40%)
Similarity:	231/404 - (57%)	Gaps:	28/404 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LWLSLWILCLFWAKCQGQLIRIPMQFQASFMASRRQH--------RAGRSSLLAKYNVVGGQEVT 63
            :|..|.:.|:.  :....|:|||::   .|.:.||..        :...:....||:..    :.
Frog     6 VWALLALCCVM--QPGSSLVRIPLK---KFTSIRRAMSETDQDALKLSGNEAATKYSAF----LN 61

  Fly    64 SRNGGATETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNAS 128
            |:| ...|||.|.|:.:|.|.|.||:|.|||.::|||||:||||||..||...:||..||:|::|
Frog    62 SKN-PTPETLLNYLDAQYYGEIGIGTPPQPFTVVFDTGSSNLWVPSIHCSFWDLACWLHHKYDSS 125

  Fly   129 ASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGLG 193
            .|:|::.:|..|:|.||:|||:|.|::|||.||.|.|..|.|..|..:||.|||...|.||:|:|
Frog   126 KSTTYINNGTEFAIQYGSGSLTGYLSKDTVTIGDLAVNGQFFAEAIKQPGITFVAAKFDGILGMG 190

  Fly   194 FRPIAELGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTHA 258
            :..|:..|:.|:|:.:.:|:|||..:|||||.||.....|||||.||.|...::|...|:.:|..
Frog   191 YPKISVDGVPPVFDDIMEQKLVDSNIFSFYLNRNPDTLPGGELLLGGTDPAFYTGDFNYMNVTRK 255

  Fly   259 GYWQFPLDVIEVAGTRIN---QNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCSE 320
            .|||..:|.:.| |.|::   ...:||.||||||:..|..|...:...:|.:|....||::.|..
Frog   256 AYWQIHMDQLSV-GDRLSLCKDGCEAIVDTGTSLITGPVEEVTALQRAIGAIPLICGEYMILCDS 319

  Fly   321 IDSLPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILGDVFIGRYYT 380
            |.|||.|.|..||:.:.|....||:..:. .|.::|||.|..:|     ...||:||||||:|||
Frog   320 IPSLPVISFTFGGRAYSLTGEQYVLKISK-AGRTVCLSGFLGLDIPPPAGPLWIIGDVFIGQYYT 383

  Fly   381 AFDAGQRRIGFAPA 394
            .||....|:|||.|
Frog   384 VFDRANDRVGFAKA 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	145/328 (44%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	142/321 (44%)
ctsd	NP_988964.1	A1_Propeptide	22..>39	CDD:311771	7/19 (37%)
ctsd	NP_988964.1	pepsin_retropepsin_like	72..396	CDD:325019	143/325 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.110