DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and Bace1

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_062077.1	Gene:	Bace1 / 29392	RGDID:	2191	Length:	501	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	111/446 - (24%)
Similarity:	182/446 - (40%)	Gaps:	91/446 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WLSLWILCLFWAKCQGQL--------IRIPMQFQASFMASRRQHRAGRS-SLLAKYNVVGGQEVT 63
            ||.||:       ..|.|        ||:|:          |...||.. .|..........|..
  Rat     7 WLLLWV-------GSGMLPAQGTHLGIRLPL----------RSGLAGPPLGLRLPRETDEEPEEP 54

  Fly    64 SRNGGATETLDN---RLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHH---H 122
            .|.|...|.:||   :....|...:::|||.|..|:|.||||:|..|.:|.         |   |
  Rat    55 GRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAP---------HPFLH 110

  Fly   123 HRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAI--GQLVVQNQTFGMATHEPGPTFVD-T 184
            ..|....|||:....:...:.|..|...|.|..|.|:|  |..|.........| |....|:: :
  Rat   111 RYYQRQLSSTYRDLRKSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAIT-ESDKFFINGS 174

  Fly   185 NFAGIVGLGFRPIA--ELGIKPLFESMCDQQLVDECVFSFYL-----KRNGSE---RKGGELLFG 239
            |:.||:||.:..||  :..::|.|:|:..|..:.. :||..|     ..|.:|   ..||.::.|
  Rat   175 NWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPN-IFSLQLCGAGFPLNQTEALASVGGSMIIG 238

  Fly   240 GVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIADTGTSLLAAPPREY- 297
            |:|.:.::|||.|.|:....|::..:..:|:.|..:..:      .::|.|:||:.|..|.:.:
  Rat   239 GIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFE 303

  Fly   298 LIINSLLGGLPTSN-------NEYLLNCSEIDSLPEIVF------IIG-----GQRFGLQPRDYV 344
            ..:.|:.....|..       .|.|: |.:..:.|..:|      ::|     ..|..:.|:.|:
  Rat   304 AAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367

  Fly   345 -----MSATNDDGSSICLSAFTLMDAEFWILGDVFIGRYYTAFDAGQRRIGFAPAA 395
                 ::.:.||    |........:...::|.|.:..:|..||..::|||||.:|
  Rat   368 RPVEDVATSQDD----CYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	92/369 (25%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	91/359 (25%)
Bace1	NP_062077.1	beta_secretase_like	72..437	CDD:133140	92/364 (25%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250\|UniProtKB:P56817	496..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810