DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5863 and Bace2

DIOPT Version :9

Sequence 1:NP_650623.1 Gene:CG5863 / 42096 FlyBaseID:FBgn0038507 Length:395 Species:Drosophila melanogaster
Sequence 2:NP_001002802.1 Gene:Bace2 / 288227 RGDID:1303241 Length:514 Species:Rattus norvegicus


Alignment Length:475 Identity:115/475 - (24%)
Similarity:186/475 - (39%) Gaps:139/475 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LISLWLSLWILCLFWAKCQGQLIRIPMQFQASF-----MASRRQHRAGRSSLLAKYNVVGGQEVT 63
            |::.||               |..:|:...|.|     :|....|||.....|      |..|:.
  Rat    12 LLAQWL---------------LRAVPVLAPAPFTLPLQVAGAANHRASTVPGL------GTPELP 55

  Fly    64 SRNGGA---------------TETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECS 113
            ..:|.|               .:.|.......|...:.||:|.|...:|.||||:|..|..|   
  Rat    56 RADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGA--- 117

  Fly   114 PKSVACHHHHRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPG 178
            |.|....:   :::.:|||:...|...::.|..||.:|.:.:|.|.|.:....:....:||    
  Rat   118 PHSYIDTY---FDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIAT---- 175

  Fly   179 PTFVDTNF-------AGIVGLGFRPIAE--LGIKPLFESMCDQQLVDECVFSFY-----LKRNGS 229
             .|...||       .||:||.:..:|:  ..::..|:|:..|..:.: :||..     |...||
  Rat   176 -IFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPD-IFSMQMCGAGLPVAGS 238

  Fly   230 ERKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIADTGTS 288
            ...||.|:.||::.:.:.|.:.|.|:....|:|..:..:|:.|..:|.:      .:||.|:||:
  Rat   239 GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 303

  Fly   289 LLAAPPREY----------LIINSLLGGLPT-------SNNE-----------YLL--NCS---E 320
            ||..|.:.:          .:|.....|..|       :|:|           ||.  |.|   .
  Rat   304 LLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFR 368

  Fly   321 IDSLPEIVF--IIGG------QRFGLQPRDYVMSATNDDGSSICLSAFTLMDAEFWILGDVFIGR 377
            |..||::..  ::|.      .|||      :.|:||    ::.:.| |:|:.            
  Rat   369 ITILPQLYIQPMMGAGFNYECYRFG------ISSSTN----ALVIGA-TVMEG------------ 410

  Fly   378 YYTAFDAGQRRIGFA--PAA 395
            :|..||..|||:|||  |.|
  Rat   411 FYVVFDRAQRRVGFAVSPCA 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5863NP_650623.1 pepsin_retropepsin_like 71..392 CDD:299705 95/381 (25%)
Asp 80..394 CDD:278455 96/376 (26%)
Bace2NP_001002802.1 beta_secretase_like 85..446 CDD:133140 98/381 (26%)
Asp 88..425 CDD:278455 94/371 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1339
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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