Protein Alignment CG5863 and Bace2

DIOPT Version :10

• Sequence 1: NP_650623.1
• Gene: CG5863 / 42096
• FlyBaseID: FBgn0038507
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: NP_001002802.1
• Gene: Bace2 / 288227
• RGDID: 1303241
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 475
• Identity: 115/475 - (24%)
• Similarity: 186/475 - (39%)
• Gaps: 139/475 - (29%)

  Fly     4 LISLWLSLWILCLFWAKCQGQLIRIPMQFQASF-----MASRRQHRAGRSSLLAKYNVVGGQEVT 63
            |::.||               |..:|:...|.|     :|....|||.....|      |..|:.
  Rat    12 LLAQWL---------------LRAVPVLAPAPFTLPLQVAGAANHRASTVPGL------GTPELP 55

  Fly    64 SRNGGA---------------TETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECS 113
            ..:|.|               .:.|.......|...:.||:|.|...:|.||||:|..|..|
  Rat    56 RADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGA--- 117

  Fly   114 PKSVACHHHHRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPG 178
            |.|....:   :::.:|||:...|...::.|..||.:|.:.:|.|.|.:....:....:||
  Rat   118 PHSYIDTY---FDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIAT---- 175

  Fly   179 PTFVDTNF-------AGIVGLGFRPIAE--LGIKPLFESMCDQQLVDECVFSFY-----LKRNGS 229
             .|...||       .||:||.:..:|:  ..::..|:|:..|..:.: :||..     |...||
  Rat   176 -IFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPD-IFSMQMCGAGLPVAGS 238

  Fly   230 ERKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIADTGTS 288
            ...||.|:.||::.:.:.|.:.|.|:....|:|..:..:|:.|..:|.:      .:||.|:||:
  Rat   239 GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 303

  Fly   289 LLAAPPREY----------LIINSLLGGLPT-------SNNE-----------YLL--NCS---E 320
            ||..|.:.:          .:|.....|..|       :|:|           ||.  |.|   .
  Rat   304 LLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFR 368

  Fly   321 IDSLPEIVF--IIGG------QRFGLQPRDYVMSATNDDGSSICLSAFTLMDAEFWILGDVFIGR 377
            |..||::..  ::|.      .|||      :.|:||    ::.:.| |:|:.
  Rat   369 ITILPQLYIQPMMGAGFNYECYRFG------ISSSTN----ALVIGA-TVMEG------------ 410

  Fly   378 YYTAFDAGQRRIGFA--PAA 395
            :|..||..|||:|||  |.|
  Rat   411 FYVVFDRAQRRVGFAVSPCA 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	Asp	80..394	CDD:394983	96/376 (26%)
Bace2	NP_001002802.1	beta_secretase_like	85..446	CDD:133140	98/381 (26%)