DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5863 and BACE2

DIOPT Version :10

Sequence 1:NP_650623.1 Gene:CG5863 / 42096 FlyBaseID:FBgn0038507 Length:395 Species:Drosophila melanogaster
Sequence 2:NP_036237.2 Gene:BACE2 / 25825 HGNCID:934 Length:518 Species:Homo sapiens


Alignment Length:414 Identity:105/414 - (25%)
Similarity:169/414 - (40%) Gaps:114/414 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 AGRSSLLAKYNVVGGQEVTSRNGGATETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPS 109
            ||.::.||..:.:.|.   |..|...|.|             ||:|.|...:|.||||:|..|..
Human    72 AGAANFLAMVDNLQGD---SGRGYYLEML-------------IGTPPQKLQILVDTGSSNFAVAG 120

  Fly   110 AECSPKSVACHHHHRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMAT 174
               :|.|....:   ::...|||:...|...::.|..||.:|.:.:|.|.|.:....:....:||
Human   121 ---TPHSYIDTY---FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIAT 179

  Fly   175 HEPGPTFVDTNF-------AGIVGLGFRPIAE--LGIKPLFESMCDQQLVDECVFSFY-----LK 225
                 .|...||       .||:||.:..:|:  ..::..|:|:..|..:.. |||..     |.
Human   180 -----IFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLP 238

  Fly   226 RNGSERKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIAD 284
            ..||...||.|:.||::.:.:.|.:.|.|:....|:|..:..:|:.|..:|.:      .:||.|
Human   239 VAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVD 303

  Fly   285 TGTSLLAAPPREY----------LIINSLLGGLPT-------SNNE-----------YLL--NCS 319
            :||:||..|.:.:          .:|.....|..|       :|:|           ||.  |.|
Human   304 SGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSS 368

  Fly   320 ---EIDSLPEIVF--IIGG------QRFGLQPRDYVMSATNDDGSSICLSAFTLMDAEFWILGDV 373
               .|..||::..  ::|.      .|||:.|      :||    ::.:.| |:|:.        
Human   369 RSFRITILPQLYIQPMMGAGLNYECYRFGISP------STN----ALVIGA-TVMEG-------- 414

  Fly   374 FIGRYYTAFDAGQRRIGFA--PAA 395
                :|..||..|:|:|||  |.|
Human   415 ----FYVIFDRAQKRVGFAASPCA 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5863NP_650623.1 Asp 80..394 CDD:394983 94/376 (25%)
BACE2NP_036237.2 beta_secretase_like 89..450 CDD:133140 99/394 (25%)

Return to query results.
Submit another query.