DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and Bace1

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_035922.4	Gene:	Bace1 / 23821	MGIID:	1346542	Length:	501	Species:	Mus musculus

Alignment Length:	450	Identity:	111/450 - (24%)
Similarity:	184/450 - (40%)	Gaps:	99/450 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WLSLWILCLFWAKCQGQL--------IRIPMQFQASFMAS-----RRQHRAGRSSLLAKYNVVGG 59
            ||.||:       ..|.|        ||:|::   |.:|.     |........|
Mouse     7 WLLLWV-------GSGMLPAQGTHLGIRLPLR---SGLAGPPLGLRLPRETDEES---------- 51

  Fly    60 QEVTSRNGGATETLDN---RLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHH 121
             |...|.|...|.:||   :....|...:::|||.|..|:|.||||:|..|.:|.         |
Mouse    52 -EEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAP---------H 106

  Fly   122 ---HHRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAI--GQLVVQNQTFGMATHEPGPTF 181
               |..|....|||:....:...:.|..|...|.|..|.|:|  |..|.........| |....|
Mouse   107 PFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAIT-ESDKFF 170

  Fly   182 VD-TNFAGIVGLGFRPIA--ELGIKPLFESMCDQQLVDECVFSFYL-----KRNGSE---RKGGE 235
            :: :|:.||:||.:..||  :..::|.|:|:..|..:.. :||..|     ..|.:|   ..||.
Mouse   171 INGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPN-IFSLQLCGAGFPLNQTEALASVGGS 234

  Fly   236 LLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDVIEVAGTRINQN------RQAIADTGTSLLAAPP 294
            ::.||:|.:.::|||.|.|:....|::..:..:|:.|..:..:      .::|.|:||:.|..|.
Mouse   235 MIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK 299

  Fly   295 REY-LIINSLLGGLPTSN-------NEYLLNCSEIDSLPEIVF------IIG-----GQRFGLQP 340
            :.: ..:.|:.....|..       .|.|: |.:..:.|..:|      ::|     ..|..:.|
Mouse   300 KVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILP 363

  Fly   341 RDYV-----MSATNDDGSSICLSAFTLMDAEFWILGDVFIGRYYTAFDAGQRRIGFAPAA 395
            :.|:     ::.:.||    |........:...::|.|.:..:|..||..::|||||.:|
Mouse   364 QQYLRPVEDVATSQDD----CYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	92/369 (25%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	91/359 (25%)
Bace1	NP_035922.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		4/29 (14%)
		beta_secretase_like	72..437	CDD:133140	91/363 (25%)
		Asp	75..416	CDD:278455	89/356 (25%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250\|UniProtKB:P56817	496..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810