DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and Cym

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001104613.1	Gene:	Cym / 229697	MGIID:	2684977	Length:	379	Species:	Mus musculus

Alignment Length:	337	Identity:	137/337 - (40%)
Similarity:	194/337 - (57%)	Gaps:	14/337 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EVTSRNG-GATETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHR 124
            |..||.| .|:|.|.|.|:.||.|.|.||:|.|.|.::|||||:.|||||..|:.|  .|.:|||
Mouse    53 EKNSRIGVVASEPLINYLDSEYFGTIYIGTPPQEFTVVFDTGSSELWVPSVYCNSK--VCRNHHR 115

  Fly   125 YNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNFAGI 189
            ::.|.|.||....:...:.||||.:.|.||.|||.:..:||.:||.|::|.|||..|..:.|.||
Mouse   116 FDPSKSITFQNLSKPLFVQYGTGRMEGFLAYDTVTVSDIVVSHQTVGLSTQEPGDIFTYSPFDGI 180

  Fly   190 VGLGFRPIAELGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVP 254
            :||.:...|.....|:|::|.::.||.:.:||.|:.||   .:|..|..|.:|::.|.|||.:||
Mouse   181 LGLAYPTFASKYSVPIFDNMMNRHLVAQDLFSVYMSRN---EQGSMLTLGAIDQSYFIGSLHWVP 242

  Fly   255 LTHAGYWQFPLDVIEVAGTRI--NQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLN 317
            :|..|||||.:|.|.:.|..:  .....|:.||||:||..|.|:.|.|..::|.:...|:::.::
Mouse   243 VTVQGYWQFTVDRITINGEVVACQGGCPAVLDTGTALLTGPGRDILNIQQVIGAVQGHNDQFDID 307

  Fly   318 CSEIDSLPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMDAEFWILGDVFIGRYYTAF 382
            |..:|.:|.:||.|.|:.|.|.|..|    || .....|.|.|. ..:..||||||||..:|:.|
Mouse   308 CWRLDIMPTVVFEIHGREFPLPPYAY----TN-QVQGFCSSGFK-QGSHMWILGDVFIREFYSVF 366

  Fly   383 DAGQRRIGFAPA 394
            |....|:|.|.|
Mouse   367 DRANNRVGLAKA 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	130/322 (40%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	127/315 (40%)
Cym	NP_001104613.1	A1_Propeptide	19..44	CDD:285240
		pepsin_retropepsin_like	64..377	CDD:299705	130/323 (40%)
		Asp	73..378	CDD:278455	127/315 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1381
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.880