DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and Ren2

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_112470.2	Gene:	Ren2 / 19702	MGIID:	97899	Length:	424	Species:	Mus musculus

Alignment Length:	413	Identity:	143/413 - (34%)
Similarity:	214/413 - (51%)	Gaps:	35/413 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WLS--------LWILCLFWAKCQGQL------IRIPMQFQASFMASRRQHRAGRSSLLAKYNVVG 58
            ||:        ||.|.|.|:.|...|      .|||::...|......:.....:.|.|::
Mouse    20 WLNQMDRRRMPLWALLLLWSPCTFSLPTGTTFERIPLKKMPSVREILEERGVDMTRLSAEW---- 80

  Fly    59 GQEVTSRNGGATE-----TLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVA 118
              :|.::....|:     .|.|.||.:|.|.|.||:|.|.|.::||||||||||||.:||...:|
Mouse    81 --DVFTKRSSLTDLISPVVLTNYLNSQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLA 143

  Fly   119 CHHHHRYNASASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVD 183
            |..|..|.:|.||:::.:|..|:|.||:|.:.|.|:||:|.:|.:.| .||||..|..|...|:.
Mouse   144 CGIHSLYESSDSSSYMENGDDFTIHYGSGRVKGFLSQDSVTVGGITV-TQTFGEVTELPLIPFML 207

  Fly   184 TNFAGIVGLGFRPIAELGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSG 248
            ..|.|::|:||...|..|:.|:|:.:..|.::.|.|||.|..| |....|||::.||.|...:.|
Mouse   208 AQFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEKVFSVYYNR-GPHLLGGEVVLGGSDPEHYQG 271

  Fly   249 SLTYVPLTHAGYWQFPLDVIEVAGTRI--NQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSN 311
            ...||.|:....||..:..:.|..:.:  .:..:.:.|||:|.::||.....:|...||......
Mouse   272 DFHYVSLSKTDSWQITMKGVSVGSSTLLCEEGCEVVVDTGSSFISAPTSSLKLIMQALGAKEKRL 336

  Fly   312 NEYLLNCSEIDSLPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILG 371
            :||:::||::.:||:|.|.:||:.:.|...|||:...| ....:|..|...||     ...|:||
Mouse   337 HEYVVSCSQVPTLPDISFNLGGRAYTLSSTDYVLQYPN-RRDKLCTVALHAMDIPPPTGPVWVLG 400

  Fly   372 DVFIGRYYTAFDAGQRRIGFAPA 394
            ..||.::||.||....|||||.|
Mouse   401 ATFIRKFYTEFDRHNNRIGFALA 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	123/332 (37%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	121/320 (38%)
Ren2	NP_112470.2	A1_Propeptide	51..76	CDD:285240	4/24 (17%)
		renin_like	98..423	CDD:133154	125/327 (38%)
		Asp	105..423	CDD:278455	121/320 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030