DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and Napsa

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_032463.1	Gene:	Napsa / 16541	MGIID:	109365	Length:	419	Species:	Mus musculus

Alignment Length:	401	Identity:	159/401 - (39%)
Similarity:	222/401 - (55%)	Gaps:	35/401 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LSLWILCLFWAKC---QGQLIRIPMQFQASFMASRRQHRAGRSSLLAKYNVVGGQEV------TS 64
            |.|.:|||.....   :.:|||:|:|         |.|...|.     .|.:.|.|.      ||
Mouse     4 LLLLLLCLLLGNLEPEEAKLIRVPLQ---------RIHLGHRI-----LNPLNGWEQLAELSRTS 54

  Fly    65 RNGG--ATETLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNA 127
            .:||  :...|...:|.:|.|.|.:|:|.|.|.::|||||:||||||..|...|:||..|||:|.
Mouse    55 TSGGNPSFVPLSKFMNTQYFGTIGLGTPPQNFTVVFDTGSSNLWVPSTRCHFFSLACWFHHRFNP 119

  Fly   128 SASSTFVPDGRRFSIAYGTGSLSGRLAQDTVAIGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGL 192
            .|||:|.|:|.:|:|.||||.|||.|:||.:.||.:.....|||.|..||...|...:|.||:||
Mouse   120 KASSSFRPNGTKFAIQYGTGRLSGILSQDNLTIGGIHDAFVTFGEALWEPSLIFALAHFDGILGL 184

  Fly   193 GFRPIAELGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTH 257
            ||..:|..|::|..::|.:|.|:::.||||||.|:.....||||:.||.|...:...||::|:|.
Mouse   185 GFPTLAVGGVQPPLDAMVEQGLLEKPVFSFYLNRDSEGSDGGELVLGGSDPAHYVPPLTFIPVTI 249

  Fly   258 AGYWQFPLDVIEVAGTRIN---QNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCS 319
            ..|||..::.::| ||.::   |...||.||||||:..|..|...:|..:||.|..|.:|.:.||
Mouse   250 PAYWQVHMESVKV-GTGLSLCAQGCSAILDTGTSLITGPSEEIRALNKAIGGYPFLNGQYFIQCS 313

  Fly   320 EIDSLPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILGDVFIGRYY 379
            :..:||.:.|.:||..|.|..:|||:.....| ..:||..|..:|     ...|||||||:|.|.
Mouse   314 KTPTLPPVSFHLGGVWFNLTGQDYVIKILQSD-VGLCLLGFQALDIPKPAGPLWILGDVFLGPYV 377

  Fly   380 TAFDAGQRRIG 390
            ..||.|.:.:|
Mouse   378 AVFDRGDKNVG 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	139/328 (42%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	137/319 (43%)
Napsa	NP_032463.1	pepsin_retropepsin_like	68..394	CDD:299705	138/323 (43%)
		Asp	72..396	CDD:278455	137/319 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.790