DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and CTSE

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_011507546.1	Gene:	CTSE / 1510	HGNCID:	2530	Length:	401	Species:	Homo sapiens

Alignment Length:	402	Identity:	166/402 - (41%)
Similarity:	230/402 - (57%)	Gaps:	23/402 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LSLWILCLFWAKCQGQLIRIPMQFQASFMASRRQHRAGRSSLLAKYN--VVGGQEVTSRNGGATE 71
            |.|.::.|...:.||.|.|:|::...| :..:.:.|:..|.....:|  ::...|..|.:..|.|
Human     5 LLLLLVLLELGEAQGSLHRVPLRRHPS-LKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKE 68

  Fly    72 TLDNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNASASSTFVPD 136
            .|.|.|::||.|.||||||.|.|.::|||||:||||||..|:  |.||..|.|:..|.|||:...
Human    69 PLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCT--SPACKTHSRFQPSQSSTYSQP 131

  Fly   137 GRRFSIAYGTGSLSGRLAQDTVA-----IGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGLGFRP 196
            |:.|||.||||||||.:..|.|:     :..|.|..|.||.:..|||.||||..|.||:|||:..
Human   132 GQSFSIQYGTGSLSGIIGADQVSAFSYQVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPS 196

  Fly   197 IAELGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTHAGYW 261
            :|..|:.|:|::|..|.|||..:||.|:..|.....|.||:|||.|.:.|||||.:||:|...||
Human   197 LAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYW 261

  Fly   262 QFPLDVIEVAGTRI--NQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCSEIDSL 324
            |..||.|:|.||.:  ::..|||.||||||:..|..:...:.:.:|..|. :.||.:.|:.::.:
Human   262 QIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPV-DGEYAVECANLNVM 325

  Fly   325 PEIVFIIGGQRFGLQPRDYVMSATND--DGSSICLSAFTLMD-----AEFWILGDVFIGRYYTAF 382
            |::.|.|.|..:.|.|..|.:.   |  ||...|.|.|..:|     ...||||||||.::|:.|
Human   326 PDVTFTINGVPYTLSPTAYTLL---DFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVF 387

  Fly   383 DAGQRRIGFAPA 394
            |.|..|:|.|||
Human   388 DRGNNRVGLAPA 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	148/334 (44%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	145/327 (44%)
CTSE	XP_011507546.1	A1_Propeptide	21..49	CDD:285240	6/28 (21%)
		Asp	77..399	CDD:278455	145/327 (44%)
		Cathespin_E	78..398	CDD:133153	143/325 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm8487
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760