Protein Alignment CG5863 and CTSD

DIOPT Version :10

• Sequence 1: NP_650623.1
• Gene: CG5863 / 42096
• FlyBaseID: FBgn0038507
• Length: 395
• Species: Drosophila melanogaster
• Sequence 2: NP_001900.1
• Gene: CTSD / 1509
• HGNCID: 2529
• Length: 412
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 170/405 - (41%)
• Similarity: 233/405 - (57%)
• Gaps: 28/405 - (6%)

  Fly    14 LCLFWAKCQGQLIRIPMQFQASFMASRR-QHRAGRS--SLLAKYNVVG-GQEVTS-RNGGATETL 73
            |||..|.... |:|||:.   .|.:.|| ....|.|  .|:||..|.. .|.|.: ..|...|.|
Human    11 LCLLAAPASA-LVRIPLH---KFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVL 71

  Fly    74 DNRLNLEYAGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNASASSTFVPDGR 138
            .|.::.:|.|.|.||:|.|.|.::|||||:||||||..|....:||..||:||:..|||:|.:|.
Human    72 KNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGT 136

  Fly   139 RFSIAYGTGSLSGRLAQDTV-----------AIGQLVVQNQTFGMATHEPGPTFVDTNFAGIVGL 192
            .|.|.||:|||||.|:||||           |:|.:.|:.|.||.||.:||.||:...|.||:|:
Human   137 SFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGM 201

  Fly   193 GFRPIAELGIKPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTH 257
            .:..|:...:.|:|:::..|:|||:.:|||||.|:...:.||||:.||.|...:.|||:|:.:|.
Human   202 AYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTR 266

  Fly   258 AGYWQFPLDVIEVAG--TRINQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCSE 320
            ..|||..||.:|||.  |...:..:||.||||||:..|..|...:...:|.:|....||::.|.:
Human   267 KAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEK 331

  Fly   321 IDSLPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILGDVFIGRYYT 380
            :.:||.|...:||:.:.|.|.||.:. .:..|.::|||.|..||     ...|||||||||||||
Human   332 VSTLPAITLKLGGKGYKLSPEDYTLK-VSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYT 395

  Fly   381 AFDAGQRRIGFAPAA 395
            .||....|:|||.||
Human   396 VFDRDNNRVGFAEAA 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	Asp	80..394	CDD:394983	145/331 (44%)
CTSD	NP_001900.1	A1_Propeptide	23..49	CDD:462326	9/28 (32%)
		Cathepsin_D2	73..408	CDD:133157	145/335 (43%)