DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5863 and Ctsd

DIOPT Version :9

Sequence 1:	NP_650623.1	Gene:	CG5863 / 42096	FlyBaseID:	FBgn0038507	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_034113.1	Gene:	Ctsd / 13033	MGIID:	88562	Length:	410	Species:	Mus musculus

Alignment Length:	394	Identity:	157/394 - (39%)
Similarity:	223/394 - (56%)	Gaps:	31/394 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LIRIPMQFQASFMASRRQHRAGRSSL--------LAKYNVVGGQEVTSRNGGATETLDNRLNLEY 81
            :||||::   .|.:.||.......|:        :.||::....:.|.   ..:|.|.|.|:.:|
Mouse    21 IIRIPLR---KFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPKTTE---PVSELLKNYLDAQY 79

  Fly    82 AGPISIGSPGQPFNMLFDTGSANLWVPSAECSPKSVACHHHHRYNASASSTFVPDGRRFSIAYGT 146
            .|.|.||:|.|.|.::|||||:||||||..|....:||..||:||:..|||:|.:|..|.|.||:
Mouse    80 YGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSSTYVKNGTSFDIHYGS 144

  Fly   147 GSLSGRLAQDTVAI---------GQLVVQNQTFGMATHEPGPTFVDTNFAGIVGLGFRPIAELGI 202
            |||||.|:||||::         ..:.|:.|.||.||.:||..||...|.||:|:|:..|:...:
Mouse   145 GSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGILGMGYPHISVNNV 209

  Fly   203 KPLFESMCDQQLVDECVFSFYLKRNGSERKGGELLFGGVDKTKFSGSLTYVPLTHAGYWQFPLDV 267
            .|:|:::..|:|||:.:|||||.|:...:.||||:.||.|...:.|.|:|:.:|...|||..:|.
Mouse   210 LPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGELSYLNVTRKAYWQVHMDQ 274

  Fly   268 IEVAG--TRINQNRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNCSEIDSLPEIVFI 330
            :||..  |......:||.|||||||..|..|...:...:|.:|....||::.|.::.|||.:...
Mouse   275 LEVGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEYMIPCEKVSSLPTVYLK 339

  Fly   331 IGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMD-----AEFWILGDVFIGRYYTAFDAGQRRIG 390
            :||:.:.|.|..|::. .:..|.:||||.|..||     ...|||||||||.|||.||....|:|
Mouse   340 LGGKNYELHPDKYILK-VSQGGKTICLSGFMGMDIPPPSGPLWILGDVFIGSYYTVFDRDNNRVG 403

  Fly   391 FAPA 394
            ||.|
Mouse   404 FANA 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5863	NP_650623.1	pepsin_retropepsin_like	71..392	CDD:299705	143/336 (43%)
CG5863	NP_650623.1	Asp	80..394	CDD:278455	141/329 (43%)
Ctsd	NP_034113.1	A1_Propeptide	21..46	CDD:285240	8/27 (30%)
		Cathepsin_D2	73..405	CDD:133157	141/332 (42%)
		Asp	78..407	CDD:278455	141/329 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100536
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.790