DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5860 and ctsd

DIOPT Version :9

Sequence 1:	NP_650622.1	Gene:	CG5860 / 42095	FlyBaseID:	FBgn0038506	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_571785.2	Gene:	ctsd / 65225	ZFINID:	ZDB-GENE-010131-8	Length:	398	Species:	Danio rerio

Alignment Length:	398	Identity:	142/398 - (35%)
Similarity:	215/398 - (54%)	Gaps:	40/398 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LAFLSLVFA----TQKILKVPL----YVRRSFNESEVFLARSATE---GGETLQLQL-------- 54
            :|||.||.|    :..|:::||    .:||:.::|    .||..|   ...:|:..|
Zfish     3 IAFLLLVVAFFCTSDAIVRIPLKKFRTLRRTLSDS----GRSLEELVSSSNSLKYNLGFPASNDP 63

  Fly    55 ---LLQTHNNMEYYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQNHRKYNSSRSSSY 116
               .|:.:.:.:|||.|.:|.|.|.|||:|||||||.|:|||:|.:::.||..|.|||..:||:|
Zfish    64 TPETLKNYLDAQYYGEIGLGTPVQTFTVVFDTGSSNLWVPSVHCSLTDIACLLHHKYNGGKSSTY 128

  Fly   117 IPDGRNFTLRYGSGMVVGYLSKDTMHIAGAELPHFTFGESLFLQHFAFSSVKFDGLVGLGLGVLS 181
            :.:|..|.::||||.:.||||:||..|....:....|||::.....||.:.||||::|:....::
Zfish   129 VKNGTQFAIQYGSGSLSGYLSQDTCTIGDIAVEKQIFGEAIKQPGVAFIAAKFDGILGMAYPRIA 193

  Fly   182 WSNTTPFLELLCAQRLLEKCVFSVYLRRDP-----REIVFGGFDESKFEGKLHYVPVSQWHTWSL 241
            .....|..:::.:|:.:||.|||.||.|:|     .|::.||.|...:.|..:||.:|:...|.:
Zfish   194 VDGVPPVFDMMMSQKKVEKNVFSFYLNRNPDTQPGGELLLGGTDPKYYTGDFNYVDISRQAYWQI 258

  Fly   242 QISKSSVGT--KQIGGKSNAILDTGTSLVLVPQQTYHNLLNTLSA-KLQNGYFVVACKS-GSLPN 302
            .:...|:|:  ....|...||:||||||:..|......|...:.| .|..|.::|.||. .:||.
Zfish   259 HMDGMSIGSGLSLCKGGCEAIVDTGTSLITGPAAEVKALQKAIGAIPLMQGEYMVDCKKVPTLPT 323

  Fly   303 INILIGDKVFPLTSSDYIMEVLLDRKPACV-----LAIAPINRGFWVLGDIFLRRYYTVFDATEK 362
            |:..:|.||:.||...||::........|:     |.|.|.....|:|||:|:.:||||||....
Zfish   324 ISFSLGGKVYSLTGEQYILKESQGGHDICLSGFMGLDIPPPAGPLWILGDVFIGQYYTVFDRENN 388

  Fly   363 RIGLAKAK 370
            |:|.||||
Zfish   389 RVGFAKAK 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5860	NP_650622.1	pepsin_retropepsin_like	61..368	CDD:299705	120/320 (38%)
CG5860	NP_650622.1	Asp	63..369	CDD:278455	121/319 (38%)
ctsd	NP_571785.2	A1_Propeptide	19..44	CDD:285240	8/28 (29%)
		Cathepsin_D2	70..394	CDD:133157	120/323 (37%)
		Asp	75..395	CDD:278455	121/319 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.880