Protein Alignment CG5860 and PGA5

DIOPT Version :9

• Sequence 1: NP_650622.1
• Gene: CG5860 / 42095
• FlyBaseID: FBgn0038506
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_055039.1
• Gene: PGA5 / 5222
• HGNCID: 8887
• Length: 388
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 135/403 - (33%)
• Similarity: 204/403 - (50%)
• Gaps: 65/403 - (16%)

  Fly     9 LAFLSLVFATQKIL-KVPLYVRRSFNESEVFLARSATEGGETLQLQLLLQTHN------------ 60
            |..|.||..::.|: ||||..::|       |.|:.:|.|   .|:..|:.||
Human     4 LLLLGLVALSECIMYKVPLIRKKS-------LRRTLSERG---LLKDFLKKHNLNPARKYFPQWE 58

  Fly    61 --------------NMEYYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQNHRKYNSS 111
                          :|||:|||.:|.|.|:|||:|||||||.|:|||.|  |:.||.||.::|..
Human    59 APTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121

  Fly   112 RSSSYIPDGRNFTLRYGSGMVVGYLSKDTMHIAGAELPHFTFGES-----LFLQHFAFSSVKFDG 171
            .||:|.......::.||:|.:.|.|..||:.:.|....:..||.|     .||.:     ..|||
Human   122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY-----APFDG 181

  Fly   172 LVGLGLGVLSWSNTTPFLELLCAQRLLEKCVFSVYLRRDPRE---IVFGGFDESKFEGKLHYVPV 233
            ::||....:|.|..||..:.:..|.|:.:.:|||||..|.:.   ::|||.|.|.:.|.|::|||
Human   182 ILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGSLNWVPV 246

  Fly   234 SQWHTWSLQISKSSVGTKQIGGKS--NAILDTGTSLVLVPQQTYHNLLNTLSA-KLQNGYFVVAC 295
            :....|.:.:...::..:.|....  .||:||||||:..|.....|:.:.:.| :..:|..||:|
Human   247 TVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSC 311

  Fly   296 KS-GSLPNINILIGDKVFPLTSSDYIMEVLLDRKPACVLAI----APINRG-FWVLGDIFLRRYY 354
            .: .|||:|...|....:|:..|.||    |..:.:|:...    .|...| .|:|||:|:|:|:
Human   312 SAISSLPDIVFTINGVQYPVPPSAYI----LQSEGSCISGFQGMNVPTESGELWILGDVFIRQYF 372

  Fly   355 TVFDATEKRIGLA 367
            ||||....::|||
Human   373 TVFDRANNQVGLA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5860	NP_650622.1	pepsin_retropepsin_like	61..368	CDD:299705	117/324 (36%)
		Asp	63..369	CDD:278455	116/322 (36%)
PGA5	NP_055039.1	A1_Propeptide	17..45	CDD:285240	11/37 (30%)
		pepsin_A	66..386	CDD:133145	117/331 (35%)
		Asp	75..387	CDD:278455	116/322 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1428
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950