DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5860 and cathD

DIOPT Version :9

Sequence 1:	NP_650622.1	Gene:	CG5860 / 42095	FlyBaseID:	FBgn0038506	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001334713.1	Gene:	cathD / 45268	FlyBaseID:	FBgn0029093	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	150/402 - (37%)
Similarity:	217/402 - (53%)	Gaps:	42/402 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLCFLLAFLSLVFA---TQK---ILKVPLY----VRRSFNESEVFLARSATEGGETLQLQLL 55
            |.:|...|:|||:...|   :|:   :|:|||:    .||.|          |..|.|..||::.
  Fly     1 MQKVALLLVAFLAAAVAHPNSQEKPGLLRVPLHKFQSARRHF----------ADVGTELQQLRIR 55

  Fly    56 ---------LQTHNNMEYYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQNHRKYNSS 111
                     |..:.:.:|||.||:|:|.|||.|:|||||||.|:||..|.::|.||..|.||::|
  Fly    56 YGGGDVPEPLSNYMDAQYYGPIAIGSPPQNFRVVFDTGSSNLWVPSKKCHLTNIACLMHNKYDAS 120

  Fly   112 RSSSYIPDGRNFTLRYGSGMVVGYLSKDTMHIAGAELPHFTFGESLFLQHFAFSSVKFDGLVGLG 176
            :|.:|..:|..|.::||||.:.||||.||:.|||.::...||.|:|......|.:.||||::|||
  Fly   121 KSKTYTKNGTEFAIQYGSGSLSGYLSTDTVSIAGLDIKDQTFAEALSEPGLVFVAAKFDGILGLG 185

  Fly   177 LGVLSWSNTTPFLELLCAQRLLEKCVFSVYLRRDPR-----EIVFGGFDESKFEGKLHYVPVSQW 236
            ...:|.....|....:..|.|:...|||.||.|||.     ||:|||.|.:.:.|:..|:||::.
  Fly   186 YNSISVDKVKPPFYAMYEQGLISAPVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRK 250

  Fly   237 HTWSLQISKSSVGTKQI-GGKSNAILDTGTSLVLVPQQTYHNLLNTL-SAKLQNGYFVVACK-SG 298
            ..|.:::..:|:|..|: .|....|.||||||:..|.:...::...: ...:..|.:||:|. ..
  Fly   251 AYWQIKMDAASIGDLQLCKGGCQVIADTGTSLIAAPLEEATSINQKIGGTPIIGGQYVVSCDLIP 315

  Fly   299 SLPNINILIGDKVFPLTSSDYIMEVLLDRKPACV-----LAIAPINRGFWVLGDIFLRRYYTVFD 358
            .||.|..::|.|.|.|...|||:.|....|..|:     |.|.|.|...|:|||:|:.:|||.||
  Fly   316 QLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKYYTEFD 380

  Fly   359 ATEKRIGLAKAK 370
            ....|:|.|.||
  Fly   381 MGNDRVGFADAK 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5860	NP_650622.1	pepsin_retropepsin_like	61..368	CDD:299705	126/319 (39%)
CG5860	NP_650622.1	Asp	63..369	CDD:278455	127/318 (40%)
cathD	NP_001334713.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455571
Domainoid	1	1.000	97	1.000	Domainoid score	I1884
eggNOG	1	0.900	-	-		E1_KOG1339
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1684
Isobase	1	0.950	-	0	Normalized mean entropy	S917
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.850