DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5860 and Bace1

DIOPT Version :9

Sequence 1:	NP_650622.1	Gene:	CG5860 / 42095	FlyBaseID:	FBgn0038506	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_062077.1	Gene:	Bace1 / 29392	RGDID:	2191	Length:	501	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	82/377 - (21%)
Similarity:	151/377 - (40%)	Gaps:	92/377 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LQTHNNMEYYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQNHRKYNSSRSSSYIPDG 120
            |:..:...||..:.:|:|.|...::.||||||..:.:...|..      ||.|....||:|....
  Rat    67 LRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLR 125

  Fly   121 RNFTLRYGSGMVVGYLSKDTMHI-------AGAELPHFTFGESLFLQHFAFSSVKFDGLVGLGLG 178
            ::..:.|..|...|.|..|.:.|       ..|.:...|..:..|:     :...::|::||...
  Rat   126 KSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI-----NGSNWEGILGLAYA 185

  Fly   179 VLSWSNTT--PFLELLCAQRLLEKCVFSVY-------------LRRDPREIVFGGFDESKFEGKL 228
            .::..:.:  ||.:.|..|..:.. :||:.             |......::.||.|.|.:.|.|
  Rat   186 EIARPDDSLEPFFDSLVKQTHIPN-IFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSL 249

  Fly   229 HYVPVSQWHTWSLQISKSSVGTKQIGGK-----------SNAILDTGTSLVLVPQQTYHNLLNTL 282
            .|.|:.:  .|..::....|   :|.|:           ..:|:|:||:.:.:|::.:...:.::
  Rat   250 WYTPIRR--EWYYEVIIVRV---EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSI 309

  Fly   283 SA-----KLQNGYF----VVACKSGSLP-NINILIGDKVFPLTSSDYIM---------------- 321
            .|     |..:|::    :|..::|:.| ||        ||:.|. |:|
  Rat   310 KAASSTEKFPDGFWLGEQLVCWQAGTTPWNI--------FPVISL-YLMGEVTNQSFRITILPQQ 365

  Fly   322 ------EVLLDRKPACVLAIAPINRGFWVLGDIFLRRYYTVFDATEKRIGLA 367
                  :|...:......|::..:.| .|:|.:.:..:|.|||...||||.|
  Rat   366 YLRPVEDVATSQDDCYKFAVSQSSTG-TVMGAVIMEGFYVVFDRARKRIGFA 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5860	NP_650622.1	pepsin_retropepsin_like	61..368	CDD:299705	81/372 (22%)
CG5860	NP_650622.1	Asp	63..369	CDD:278455	81/370 (22%)
Bace1	NP_062077.1	beta_secretase_like	72..437	CDD:133140	81/372 (22%)
		Interaction with RTN3. /evidence=ECO:0000250	479..501
		DXXLL. /evidence=ECO:0000250\|UniProtKB:P56817	496..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900