DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5860 and BACE1

DIOPT Version :9

Sequence 1:	NP_650622.1	Gene:	CG5860 / 42095	FlyBaseID:	FBgn0038506	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_036236.1	Gene:	BACE1 / 23621	HGNCID:	933	Length:	501	Species:	Homo sapiens

Alignment Length:	457	Identity:	99/457 - (21%)
Similarity:	172/457 - (37%)	Gaps:	131/457 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLCFLLAFLSL----VFATQKILKVPLYVRRSFNESEVFLARSATEGGETLQLQLLLQTHNN 61
            |.:.|.:||.::..    ...||..:::||              ||.. ||..|.|:|..:|...
Human     1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPL--------------RSGL-GGAPLGLRLPRETDEE 50

  Fly    62 ME----------------------YYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQN 104
            .|                      ||..:.:|:|.|...::.||||||..:.:...|..
Human    51 PEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------ 109

  Fly   105 HRKYNSSRSSSYIPDGRNFTLRYGSGMVVGYLSKDTMHI-------AGAELPHFTFGESLFLQHF 162
            ||.|....||:|....:...:.|..|...|.|..|.:.|       ..|.:...|..:..|:
Human   110 HRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI--- 171

  Fly   163 AFSSVKFDGLVGLGLGVLSWSNTT--PFLELLCAQR------LLEKCVFSVYLRRDP------RE 213
              :...::|::||....::..:.:  ||.:.|..|.      .|:.|.....|.:..      ..
Human   172 --NGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGS 234

  Fly   214 IVFGGFDESKFEGKLHYVPVSQWHTWSLQISKSSVGTKQIGGK-----------SNAILDTGTSL 267
            ::.||.|.|.:.|.|.|.|:.:  .|..::....|   :|.|:           ..:|:|:||:.
Human   235 MIIGGIDHSLYTGSLWYTPIRR--EWYYEVIIVRV---EINGQDLKMDCKEYNYDKSIVDSGTTN 294

  Fly   268 VLVPQQTYHNLLNTLSA-----KLQNGYF----VVACKSGSLP-NINILIGDKVFPLTSSDYIM- 321
            :.:|::.:...:.::.|     |..:|::    :|..::|:.| ||        ||:.|. |:|
Human   295 LRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNI--------FPVISL-YLMG 350

  Fly   322 ---------------------EVLLDRKPACVLAIAPINRGFWVLGDIFLRRYYTVFDATEKRIG 365
                                 :|...:......||:..:.| .|:|.:.:..:|.|||...||||
Human   351 EVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTG-TVMGAVIMEGFYVVFDRARKRIG 414

  Fly   366 LA 367
            .|
Human   415 FA 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5860	NP_650622.1	pepsin_retropepsin_like	61..368	CDD:299705	83/393 (21%)
CG5860	NP_650622.1	Asp	63..369	CDD:278455	83/391 (21%)
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		5/18 (28%)
		beta_secretase_like	72..437	CDD:133140	82/371 (22%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269\|PubMed:15886016	496..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810