DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5860 and Ren2

DIOPT Version :9

Sequence 1:	NP_650622.1	Gene:	CG5860 / 42095	FlyBaseID:	FBgn0038506	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_112470.2	Gene:	Ren2 / 19702	MGIID:	97899	Length:	424	Species:	Mus musculus

Alignment Length:	350	Identity:	126/350 - (36%)
Similarity:	194/350 - (55%)	Gaps:	17/350 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ESEVFLARSATEGGETLQLQLLLQTHNNMEYYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMS 98
            |.:||..||:.   ..|...::|..:.|.:|||.|.:|.|.|.|.|||||||:|.|:||..|...
Mouse    79 EWDVFTKRSSL---TDLISPVVLTNYLNSQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRL 140

  Fly    99 NSACQNHRKYNSSRSSSYIPDGRNFTLRYGSGMVVGYLSKDTMHIAGAELPHFTFGESLFLQHFA 163
            ..||..|..|.||.||||:.:|.:||:.||||.|.|:||:|::.:.|..:.. ||||...|....
Mouse   141 YLACGIHSLYESSDSSSYMENGDDFTIHYGSGRVKGFLSQDSVTVGGITVTQ-TFGEVTELPLIP 204

  Fly   164 FSSVKFDGLVGLGLGVLSWSNTTPFLELLCAQRLLEKCVFSVYLRRDPR----EIVFGGFDESKF 224
            |...:|||::|:|....:....||..:.:.:|.:|::.|||||..|.|.    |:|.||.|...:
Mouse   205 FMLAQFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEKVFSVYYNRGPHLLGGEVVLGGSDPEHY 269

  Fly   225 EGKLHYVPVSQWHTWSLQISKSSVGTKQIGGKS--NAILDTGTSLVLVPQQTYHNLLNTLSAKLQ 287
            :|..|||.:|:..:|.:.:...|||:..:..:.  ..::|||:|.:..|..:...::..|.||.:
Mouse   270 QGDFHYVSLSKTDSWQITMKGVSVGSSTLLCEEGCEVVVDTGSSFISAPTSSLKLIMQALGAKEK 334

  Fly   288 NGY-FVVACKS-GSLPNINILIGDKVFPLTSSDYIMEVLLDRKPACVLA-----IAPINRGFWVL 345
            ..: :||:|.. .:||:|:..:|.:.:.|:|:||:::....|...|.:|     |.|.....|||
Mouse   335 RLHEYVVSCSQVPTLPDISFNLGGRAYTLSSTDYVLQYPNRRDKLCTVALHAMDIPPPTGPVWVL 399

  Fly   346 GDIFLRRYYTVFDATEKRIGLAKAK 370
            |..|:|::||.||....|||.|.|:
Mouse   400 GATFIRKFYTEFDRHNNRIGFALAR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5860	NP_650622.1	pepsin_retropepsin_like	61..368	CDD:299705	117/319 (37%)
CG5860	NP_650622.1	Asp	63..369	CDD:278455	117/318 (37%)
Ren2	NP_112470.2	A1_Propeptide	51..76	CDD:285240
		renin_like	98..423	CDD:133154	119/325 (37%)
		Asp	105..423	CDD:278455	117/318 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020