Protein Alignment CG5860 and bace2

DIOPT Version :10

• Sequence 1: NP_650622.1
• Gene: CG5860 / 42095
• FlyBaseID: FBgn0038506
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_001135590.1
• Gene: bace2 / 100216145
• XenbaseID: XB-GENE-1014090
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 360
• Identity: 88/360 - (24%)
• Similarity: 160/360 - (44%)
• Gaps: 64/360 - (17%)

  Fly    60 NNME------YYGTIAMGNPRQNFTVIFDTGSSNTWLPSVNCPMSNSACQNHRKYNSSRSSSYIP 118
            ||:|      ||..:.:|.|.|...::.||||||..:.....|...:.      ::|..|:||.|
 Frog    65 NNLEGDSGRGYYLELLIGTPPQKMNILVDTGSSNFAVAGALNPDITTF------FDSKLSTSYEP 123

  Fly   119 DGRNFTLRYGSGMVVGYLSKDTMHIAGAELPHFTFG------ESLF-LQHFAFSSVKFDGLVGLG 176
            .....|:||..|...|.|.||.:     .:|....|      .|:| .::|...::.:.|::||.
 Frog   124 LNTQVTVRYTQGSWTGLLGKDVI-----SMPKGVNGTFLINIASIFQSENFFLPNINWQGILGLA 183

  Fly   177 LGVLS--WSNTTPFLELLCAQRLLEKCVFSVYL----RRDP------REIVFGGFDESKFEGKLH 229
            ...|:  .|:..||.:.|..|..:.. :||:.:    :..|      ..:|.||.:.|.::|.:.
 Frog   184 YSTLAKPSSSVEPFFDSLVQQENIPN-IFSMQMCGAGQPSPGIGINAGSLVLGGIEPSLYQGDIW 247

  Fly   230 YVPVSQWHTWSLQISKSSVGTKQIG------GKSNAILDTGTSLVLVPQQTYHNLLNTL--SAKL 286
            |.|:::...:.:::.|..||.:.:.      ....||:|:||:|:.:|.:.::.:::.:  ::.:
 Frog   248 YTPITEEWYYQVEVLKFEVGGQNLNLDCTVYNSDKAIVDSGTTLLRLPDKVFNAMVDAIVQTSLI 312

  Fly   287 QN------GYFVVACKSGS------LPNINILIGD----KVFPLTSSD--YIMEVLLDRKPA-CV 332
            ||      ....:||...:      .|:|:|.:.|    :.|.||...  ||..||..::.. |.
 Frog   313 QNFNAEFWAGLQLACWDKTQDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQSVLTFQESLNCF 377

  Fly   333 LAIAPINRGFWVLGDIFLRRYYTVFDATEKRIGLA 367
            ......:....|:|...:..:|.:||..|||:|.|
 Frog   378 RFGISQSASALVIGATVMEGFYVIFDRAEKRVGFA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5860	NP_650622.1	Asp	63..369	CDD:394983	86/357 (24%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	85/353 (24%)