DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17283 and PGA4

DIOPT Version :9

Sequence 1:	NP_650621.1	Gene:	CG17283 / 42094	FlyBaseID:	FBgn0038505	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001073276.1	Gene:	PGA4 / 643847	HGNCID:	8886	Length:	388	Species:	Homo sapiens

Alignment Length:	327	Identity:	127/327 - (38%)
Similarity:	186/327 - (56%)	Gaps:	18/327 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LKNTANMEYTCKMNIGTPKQKFTVLPDTGSSNIWVPGPHCKSKACKKHKQYHPAKSSTYVKNGKS 206
            |:|..:|||...:.||||.|.|||:.||||||:|||..:|.|.||..|.:::|..||||....::
Human    68 LENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSET 132

  Fly   207 FAITYGSGSVAGVLAKDTVRIAGLVVTNQTFAMTTKEPGTTFVTSNFDGILGLGYRSIAVDNVKT 271
            .:||||:||:.|:|..|||::.|:..|||.|.::..|||:....:.|||||||.|.||:......
Human   133 VSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATP 197

  Fly   272 LVQNMCSEDVITSCKFAICMKGGGSSSRGGAIIFGSSNTSAYSGSNSYTYTPVTKKGYWQFTLQD 336
            :..|:.::.:::...|::.:.....|  |..:|||..::|.|:|  |..:.|||.:||||.|:..
Human   198 VFDNIWNQGLVSQDLFSVYLSADDQS--GSVVIFGGIDSSYYTG--SLNWVPVTVEGYWQITVDS 258

  Fly   337 IYVGGTKV--SGSVQAIVDSGTSLITAPTAIYNKINKVIGCRATSSGECWMKCA--KKIPDFTFV 397
            |.:.|..:  :...|||||:||||:|.||:....|...||....|.|:..:.|:  ..:||..|.
Human   259 ITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFT 323

  Fly   398 IAGKKFVVKGNKMKLKVRTNRGRTVCISAV--TEVPDEP---VILGDAFIRHFCTEFDLANNRIG 457
            |.|.::.|..:...|:...:     |||..  ..:|.|.   .||||.|||.:.|.||.|||::|
Human   324 INGVQYPVPPSAYILQSEGS-----CISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVG 383

  Fly   458 FA 459
            .|
Human   384 LA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17283	NP_650621.1	pepsin_retropepsin_like	142..459	CDD:299705	126/325 (39%)
CG17283	NP_650621.1	Asp	149..460	CDD:278455	124/320 (39%)
PGA4	NP_001073276.1	A1_Propeptide	17..45	CDD:311771
PGA4	NP_001073276.1	pepsin_A	66..386	CDD:133145	127/327 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830