Protein Alignment CG17283 and BACE2

DIOPT Version :10

• Sequence 1: NP_650621.1
• Gene: CG17283 / 42094
• FlyBaseID: FBgn0038505
• Length: 465
• Species: Drosophila melanogaster
• Sequence 2: NP_036237.2
• Gene: BACE2 / 25825
• HGNCID: 934
• Length: 518
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 104/408 - (25%)
• Similarity: 169/408 - (41%)
• Gaps: 108/408 - (26%)

  Fly   110 NFVRTTDNLRSEKAFLANRYGFSFAKSSGTATLKNTANMEYTCKMNIGTPKQKFTVLPDTGSSNI 174
            ||:...|||:.:               ||..         |..:|.||||.||..:|.||||||.
Human    76 NFLAMVDNLQGD---------------SGRG---------YYLEMLIGTPPQKLQILVDTGSSNF 116

  Fly   175 WVPG-PHCKSKACKKHKQYHPAKSSTYVKNGKSFAITYGSGSVAGVLAKDTVRI-AGLVVTNQTF 237
            .|.| ||.....     .:...:||||...|....:.|..||..|.:.:|.|.| .|.   |.:|
Human   117 AVAGTPHSYIDT-----YFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGF---NTSF 173

  Fly   238 AMTTKEPGTTFVTSNF-------DGILGLGYRSIA--VDNVKTLVQNMCSEDVITSCKFAICMKG 293
            .:..   .|.|.:.||       :|||||.|.::|  ..:::|...::.::..|.:. |::.|.|
Human   174 LVNI---ATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV-FSMQMCG 234

  Fly   294 -----GGSSSRGGAIIFGSSNTSAYSGSNSYTYTPVTKKGYWQFTLQDIYVGGTKVS------GS 347
                 .||.:.||:::.|....|.|.|  ...|||:.::.|:|..:..:.:||..::      .:
Human   235 AGLPVAGSGTNGGSLVLGGIEPSLYKG--DIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNA 297

  Fly   348 VQAIVDSGTSLITAPTAIYNKINKVIGCRAT-----SSG-------ECWMKCAKKIPDFTFVIAG 400
            .:|||||||:|:..|..:::.:.:.: .||:     |.|       .||.........|.
Human   298 DKAIVDSGTTLLRLPQKVFDAVVEAV-ARASLIPEFSDGFWTGSQLACWTNSETPWSYFP----- 356

  Fly   401 KKFVVKGNKMKLKVR-TNRGRTVCISAVTEVPDEP---------------------VILGDAFIR 443
                    |:.:.:| .|..|:..|:.:.::..:|                     :::|...:.
Human   357 --------KISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVME 413

  Fly   444 HFCTEFDLANNRIGFAAT 461
            .|...||.|..|:||||:
Human   414 GFYVIFDRAQKRVGFAAS 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17283	NP_650621.1	Asp	149..460	CDD:394983	95/366 (26%)
BACE2	NP_036237.2	beta_secretase_like	89..450	CDD:133140	98/380 (26%)