DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17283 and Ctse

DIOPT Version :9

Sequence 1:	NP_650621.1	Gene:	CG17283 / 42094	FlyBaseID:	FBgn0038505	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_006249810.1	Gene:	Ctse / 25424	RGDID:	2446	Length:	398	Species:	Rattus norvegicus

Alignment Length:	327	Identity:	134/327 - (40%)
Similarity:	186/327 - (56%)	Gaps:	13/327 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LKNTANMEYTCKMNIGTPKQKFTVLPDTGSSNIWVPGPHCKSKACKKHKQYHPAKSSTYVKNGKS 206
            |.|..:|||...::||:|.|.|||:.||||||:|||..:|.|.|||.|..:||::||||::.|..
  Rat    72 LINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSSTYMEVGNH 136

  Fly   207 FAITYGSGSVAGVLAKDTVRIAGLVVTNQTFAMTTKEPGTTFVTSNFDGILGLGYRSIAVDNVKT 271
            |:|.||:||:.|::..|.|.:.||.|..|.|..:.||||.|||.:.|||||||||.|:||..|..
  Rat   137 FSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTP 201

  Fly   272 LVQNMCSEDVITSCKFAICMKGGGSSSRGGAIIFGSSNTSAYSGSNSYTYTPVTKKGYWQFTLQD 336
            :..||.:::::....|::.:........|..:.||..:.|.:||  |..:.||||:||||..|..
  Rat   202 VFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSG--SLNWIPVTKQGYWQIALDG 264

  Fly   337 IYVGGTKV--SGSVQAIVDSGTSLITAPTAIYNKINKVIGCRATSSGECWMKCA--KKIPDFTFV 397
            |.||.|.:  |...|||||:||||||.|.....::.:.||. ....||..:.||  ..:|:.||:
  Rat   265 IQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGA-TPMDGEYAVDCATLNMMPNVTFL 328

  Fly   398 IAGKKFVVKGNKMKLKVRTNRGRTVCISAVTEVPDEPV-----ILGDAFIRHFCTEFDLANNRIG 457
            |.|..:.:......|....: |...|.|....:..:|.     ||||.|||.|.:.||..||::|
  Rat   329 INGVSYTLSPTAYILPDLVD-GMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVG 392

  Fly   458 FA 459
            .|
  Rat   393 LA 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17283	NP_650621.1	pepsin_retropepsin_like	142..459	CDD:299705	133/325 (41%)
CG17283	NP_650621.1	Asp	149..460	CDD:278455	131/320 (41%)
Ctse	XP_006249810.1	A1_Propeptide	23..51	CDD:285240
		Asp	79..396	CDD:278455	131/320 (41%)
		pepsin_retropepsin_like	80..395	CDD:299705	130/319 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.760