DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17283 and Ren2

DIOPT Version :9

Sequence 1:	NP_650621.1	Gene:	CG17283 / 42094	FlyBaseID:	FBgn0038505	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_112470.2	Gene:	Ren2 / 19702	MGIID:	97899	Length:	424	Species:	Mus musculus

Alignment Length:	343	Identity:	119/343 - (34%)
Similarity:	182/343 - (53%)	Gaps:	20/343 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 FAKSS------GTATLKNTANMEYTCKMNIGTPKQKFTVLPDTGSSNIWVPGPHCKS--KACKKH 189
            |.|.|      ....|.|..|.:|..::.||||.|.|.|:.||||:|:|||...|..  .||..|
Mouse    83 FTKRSSLTDLISPVVLTNYLNSQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIH 147

  Fly   190 KQYHPAKSSTYVKNGKSFAITYGSGSVAGVLAKDTVRIAGLVVTNQTFAMTTKEPGTTFVTSNFD 254
            ..|..:.||:|::||..|.|.||||.|.|.|::|:|.:.|:.|| |||...|:.|...|:.:.||
Mouse   148 SLYESSDSSSYMENGDDFTIHYGSGRVKGFLSQDSVTVGGITVT-QTFGEVTELPLIPFMLAQFD 211

  Fly   255 GILGLGYRSIAVDNVKTLVQNMCSEDVITSCKFAICMKGGGSSSRGGAIIFGSSNTSAYSGSNSY 319
            |:||:|:.:.||..|..:..::.|:.|:....|:: ....|....||.::.|.|:...|.|  .:
Mouse   212 GVLGMGFPAQAVGGVTPVFDHILSQGVLKEKVFSV-YYNRGPHLLGGEVVLGGSDPEHYQG--DF 273

  Fly   320 TYTPVTKKGYWQFTLQDIYVGGTKV--SGSVQAIVDSGTSLITAPTAIYNKINKVIGCRATSSGE 382
            .|..::|...||.|::.:.||.:.:  ....:.:||:|:|.|:|||:....|.:.:|.:.....|
Mouse   274 HYVSLSKTDSWQITMKGVSVGSSTLLCEEGCEVVVDTGSSFISAPTSSLKLIMQALGAKEKRLHE 338

  Fly   383 CWMKCAK--KIPDFTFVIAGKKFVVKGNKMKLKVRTNRGR--TVCISAV-TEVPDEPV-ILGDAF 441
            ..:.|::  .:||.:|.:.|:.:.:......|:....|.:  ||.:.|: ...|..|| :||..|
Mouse   339 YVVSCSQVPTLPDISFNLGGRAYTLSSTDYVLQYPNRRDKLCTVALHAMDIPPPTGPVWVLGATF 403

  Fly   442 IRHFCTEFDLANNRIGFA 459
            ||.|.||||..|||||||
Mouse   404 IRKFYTEFDRHNNRIGFA 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17283	NP_650621.1	pepsin_retropepsin_like	142..459	CDD:299705	114/326 (35%)
CG17283	NP_650621.1	Asp	149..460	CDD:278455	113/321 (35%)
Ren2	NP_112470.2	A1_Propeptide	51..76	CDD:285240
		renin_like	98..423	CDD:133154	116/328 (35%)
		Asp	105..423	CDD:278455	113/321 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930