DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_598582.3	Gene:	Phlpp1 / 98432	MGIID:	2138327	Length:	1687	Species:	Mus musculus

Alignment Length:	517	Identity:	138/517 - (26%)
Similarity:	225/517 - (43%)	Gaps:	116/517 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 IKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQ 226
            :|.|:||.:.:...||.|.....|.||.:..|.:.::|..:|.:.:|:...|:.|.|.|||..|:
Mouse   649 LKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNALREVPAAVGDMQNLQTFLLDGNFLQSLPAELE 713

  Fly   227 NCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFN-----RITA-------------------- 266
            :..||..|.|..|:..:||.|:.:|.::..|.:..|     |:.|
Mouse   714 SMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCVETLRLQALRRMPHIKHVDLRLNILRKL 778

  Fly   267 VADDLRQLVNLTMLSLRENKIRELGSAI-----------GALVNLTT------------------ 302
            :||::..:.::|.|.||:||:.:|.:.|           ..||.|..
Mouse   779 MADEVDFVQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNVCGYFLKALYASSNELAQL 843

  Fly   303 -----------LDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRL 356
                       :|||.|.||.:||.:.....|..||:.||::.::|..:....||.:|...:|||
Mouse   844 DVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNRL 908

  Fly   357 SSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSIN 421
            :.:|..|:. .|::..:|:.|.||:||..:|.....|..:..|.|:..:.|   ||      :::
Mouse   909 ARLPERLER-TSVEVLDVQHNQITELPPNLLMKADSLRFLNASANKLETLP---PA------TLS 963

  Fly   422 LEHNRIDKIPYGIFSRAKGLTKLNMKENMLT--ALPLDIGTWVNMVELNLATNALQKLPDDIM-N 483
            .|.:.|             |.:|.:..|.||  .:||..| ...:..|::|.|.||..|...| .
Mouse   964 EETSSI-------------LQELYLTNNCLTDKCVPLLTG-HPRLKILHMAYNRLQSFPASKMAK 1014

  Fly   484 LQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPR 548
            |:.||.:.:|.|.||.||.||.|.|::..:....|.|||.| |:..|.|::.:.|..|:
Mouse  1015 LEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEVKCVDLSCNE------ 1072

  Fly   549 SIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNIDK 610
                   |:.:::.||    ||.:      |:.|.:..||.|......|.|..|::...||:
Mouse  1073 -------LSEITLPEN----LPPK------LQELDLTGNPRLALDHKSLELLNNIRCFKIDQ 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/20 (35%)
		leucine-rich repeat	185..207	CDD:275380	6/21 (29%)
		LRR_RI	204..401	CDD:238064	66/261 (25%)
		LRR_8	207..264	CDD:290566	19/61 (31%)
		leucine-rich repeat	208..230	CDD:275380	8/21 (38%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	21/122 (17%)
		leucine-rich repeat	254..276	CDD:275380	6/46 (13%)
		leucine-rich repeat	277..299	CDD:275380	9/32 (28%)
		LRR_8	299..356	CDD:290566	19/85 (22%)
		leucine-rich repeat	300..322	CDD:275380	9/50 (18%)
		leucine-rich repeat	323..345	CDD:275380	6/21 (29%)
		LRR_8	344..403	CDD:290566	19/58 (33%)
		leucine-rich repeat	346..368	CDD:275380	7/21 (33%)
		leucine-rich repeat	369..392	CDD:275380	7/22 (32%)
		LRR_RI	<379..566	CDD:238064	54/189 (29%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		leucine-rich repeat	441..486	CDD:275380	16/47 (34%)
		LRR_8	463..520	CDD:290566	21/57 (37%)
		leucine-rich repeat	487..507	CDD:275380	10/19 (53%)
		leucine-rich repeat	510..532	CDD:275380	7/21 (33%)
		LRR_8	532..588	CDD:290566	10/55 (18%)
		leucine-rich repeat	556..578	CDD:275380	5/21 (24%)
		leucine-rich repeat	603..626	CDD:275380	2/8 (25%)
Phlpp1	NP_598582.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..406
		PH_PHLPP-like	491..587	CDD:270131
		PH	511..592	CDD:278594
		LRR_RI	581..885	CDD:238064	60/235 (26%)
		LRR_8	594..659	CDD:290566	4/9 (44%)
		LRR 1	594..615
		leucine-rich repeat	597..617	CDD:275380
		LRR 2	617..638
		leucine-rich repeat	618..648	CDD:275380
		LRR_8	647..726	CDD:290566	25/76 (33%)
		LRR 3	648..669		7/19 (37%)
		LRR 4	671..692		6/20 (30%)
		leucine-rich repeat	672..694	CDD:275380	6/21 (29%)
		LRR 5	694..715		8/20 (40%)
		leucine-rich repeat	695..717	CDD:275380	8/21 (38%)
		LRR 6	717..739		8/21 (38%)
		leucine-rich repeat	718..740	CDD:275380	8/21 (38%)
		LRR 7	740..760		4/19 (21%)
		leucine-rich repeat	741..764	CDD:275380	4/22 (18%)
		LRR 8	764..785		2/20 (10%)
		LRR_RI	768..1030	CDD:238064	72/285 (25%)
		leucine-rich repeat	768..788	CDD:275380	2/19 (11%)
		LRR 9	788..809		8/20 (40%)
		leucine-rich repeat	789..809	CDD:275380	8/19 (42%)
		leucine-rich repeat	810..851	CDD:275380	3/40 (8%)
		LRR 10	829..850		0/20 (0%)
		LRR 11	851..872		8/20 (40%)
		leucine-rich repeat	852..874	CDD:275380	8/21 (38%)
		LRR 12	874..895		6/20 (30%)
		leucine-rich repeat	875..897	CDD:275380	6/21 (29%)
		LRR_8	896..954	CDD:290566	19/58 (33%)
		LRR 13	897..918		8/21 (38%)
		leucine-rich repeat	898..919	CDD:275380	7/21 (33%)
		LRR 14	919..940		8/20 (40%)
		leucine-rich repeat	920..943	CDD:275380	7/22 (32%)
		LRR 15	943..964		6/29 (21%)
		leucine-rich repeat	944..967	CDD:275380	7/31 (23%)
		LRR 16	969..989		8/32 (25%)
		LRR_8	970..1028	CDD:290566	20/58 (34%)
		leucine-rich repeat	970..993	CDD:275380	8/23 (35%)
		LRR 17	993..1014		7/20 (35%)
		leucine-rich repeat	994..1017	CDD:275380	8/22 (36%)
		LRR 18	1017..1038		10/20 (50%)
		LRR 19	1040..1061		6/21 (29%)
		LRR 20	1062..1083		6/37 (16%)
		leucine-rich repeat	1063..1085	CDD:275380	7/38 (18%)
		LRR 21	1085..1106		6/26 (23%)
		PP2Cc	1124..1376	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1604..1687
		PDZ-binding	1685..1687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940