Protein Alignment Sur-8 and MFHAS1

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_004216.2
• Gene: MFHAS1 / 9258
• HGNCID: 16982
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 123/434 - (28%)
• Similarity: 190/434 - (43%)
• Gaps: 81/434 - (18%)

  Fly   198 LPPEIGCLVSLRNLALNENSLTSLPESLQNC-SQLKVLDLRHNKLAEIPPVIYRL-RSLTTLYLR 260
            ||..:|   .:..|.|..|.|..:||.|.:. ..|:||.||.|:.|.:||.:..| ..||.|.:.
Human    58 LPANLG---DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119

  Fly   261 FNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSA 325
            .||:||:..::                      :.||..|..|::|||.|..||..:|...:|..
Human   120 HNRLTALGAEV----------------------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162

  Fly   326 LDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASL 390
            ||:..|.|..:|||:..|..|..|.:.:|:|::.|..|....:::|.:|..|.:..||:. :::|
Human   163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED-ISAL 226

  Fly   391 SGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALP 455
            ..|..:.||..:..:.|.|                         |.....|..|.:..|.|.|||
Human   227 RALKILWLSGAELGTLPAG-------------------------FCELASLESLMLDNNGLQALP 266

  Fly   456 LDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRI 520
            ........:..|||::|..::.|..::.|..||.|.||.|.|..:|:.|..|.:|..|.|:.|||
Human   267 AQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRI 331

  Fly   521 EVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYIN 585
            ..||..|..|..|:.|:||.|||.:||   .|.|.|:.:.:.:                    |.
Human   332 RYLPDSIVELTGLEELVLQGNQIAVLP---DHFGQLSRVGLWK--------------------IK 373

  Fly   586 QNPGLEKLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGPSLVL 629
            .|| |.:.|:|:.: :.:.|:...:..|:...|.:|   |.|.|
Human   374 DNP-LIQPPYEVCM-KGIPYIAAYQKELAHSQPAVQ---PRLKL 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380
		LRR	185..535	CDD:443914	99/338 (29%)
		leucine-rich repeat	185..207	CDD:275380	3/8 (38%)
		leucine-rich repeat	208..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..253	CDD:275380	10/22 (45%)
		leucine-rich repeat	254..276	CDD:275380	7/21 (33%)
		leucine-rich repeat	277..299	CDD:275380	2/21 (10%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	9/21 (43%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	6/22 (27%)
		leucine-rich repeat	417..440	CDD:275380	1/22 (5%)
		leucine-rich repeat	441..486	CDD:275380	13/44 (30%)
		PPP1R42	472..617	CDD:455733	43/144 (30%)
		leucine-rich repeat	487..507	CDD:275380	9/19 (47%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		leucine-rich repeat	556..578	CDD:275380	1/21 (5%)
		leucine-rich repeat	603..626	CDD:275380	4/22 (18%)
MFHAS1	NP_004216.2	LRR	27..434	CDD:443914	123/434 (28%)
		Required for interaction with PPP2R2A. /evidence=ECO:0000269|PubMed:28609714	64..649		120/425 (28%)
		Required for interaction with PJA2. /evidence=ECO:0000269|PubMed:28471450	64..364		106/350 (30%)
		leucine-rich repeat	68..88	CDD:275380	7/19 (37%)
		leucine-rich repeat	89..112	CDD:275380	10/22 (45%)
		leucine-rich repeat	113..136	CDD:275380	9/44 (20%)
		leucine-rich repeat	137..182	CDD:275380	18/44 (41%)
		leucine-rich repeat	160..173	CDD:275380	5/12 (42%)
		leucine-rich repeat	183..205	CDD:275380	6/21 (29%)
		leucine-rich repeat	206..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..251	CDD:275380	6/46 (13%)
		leucine-rich repeat	252..274	CDD:275380	7/21 (33%)
		leucine-rich repeat	275..297	CDD:275380	6/21 (29%)
		leucine-rich repeat	298..320	CDD:275380	10/21 (48%)
		leucine-rich repeat	321..343	CDD:275380	10/21 (48%)
		leucine-rich repeat	344..364	CDD:275380	11/22 (50%)
		P-loop containing Nucleoside Triphosphate Hydrolases	409..>552	CDD:476819	2/4 (50%)
		COR	660..>727	CDD:406489