Protein Alignment Sur-8 and LRRC8C

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: XP_006711023.1
• Gene: LRRC8C / 84230
• HGNCID: 25075
• Length: 808
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 132/526 - (25%)
• Similarity: 220/526 - (41%)
• Gaps: 145/526 - (27%)

  Fly   109 NENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSIT 173
            |.||...|.:.|.|:.|..|                                  .||:|....::
Human   409 NLNNEWTPDKLRQKLQTNAH----------------------------------NRLELPLIMLS 439

  Fly   174 VIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENS-------LTSLPESLQNCSQL 231
            .:|.||.|...|..|.|...|...:|..|..|.:|:.|:|::.|       |:.|.|:      |
Human   440 GLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN------L 498

  Fly   232 KVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGA 296
            |||.::.:.:.|:||.:|.||:|..|||                                  :|:
Human   499 KVLSVKFDDMRELPPWMYGLRNLEELYL----------------------------------VGS 529

  Fly   297 LVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPA 361
            |        ||                   |:..|..|   :|:.:||||..|.::.| :|.:|.
Human   530 L--------SH-------------------DISRNVTL---ESLRDLKSLKILSIKSN-VSKIPQ 563

  Fly   362 TLKNCKS-MDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHN 425
            .:.:..| :.:..:..:| |:|.  ||.:|..:|.:|                     .:.|.|.
Human   564 AVVDVSSHLQKMCIHNDG-TKLV--MLNNLKKMTNLT---------------------ELELVHC 604

  Fly   426 RIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVN---MVELNLATNALQKLPDDIMNLQNL 487
            .:::||:.:|| ...|.:|::|||.|.::. :|.::.:   :..|.|..|::..:|:.|..|.:|
Human   605 DLERIPHAVFS-LLSLQELDLKENNLKSIE-EIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSL 667

  Fly   488 EILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGH 552
            |.|..|:|.::.:|:.:....|:|.|||..|.|..:|.|||:|..||...:..|::..||..:..
Human   668 ERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYF 732

  Fly   553 LGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKY--LNIDKCPLST 615
            ...|..|.:.:|:|..|..:||:|..|..|.:..| ..|.||.||..|:.||.  |.::.....|
Human   733 CKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGN-HFEILPPELGDCRALKRAGLVVEDALFET 796

  Fly   616 IPPEIQ 621
            :|.:::
Human   797 LPSDVR 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/20 (35%)
		LRR	185..535	CDD:443914	91/360 (25%)
		leucine-rich repeat	185..207	CDD:275380	7/21 (33%)
		leucine-rich repeat	208..230	CDD:275380	7/28 (25%)
		leucine-rich repeat	231..253	CDD:275380	9/21 (43%)
		leucine-rich repeat	254..276	CDD:275380	4/21 (19%)
		leucine-rich repeat	277..299	CDD:275380	2/21 (10%)
		leucine-rich repeat	300..322	CDD:275380	2/21 (10%)
		leucine-rich repeat	323..345	CDD:275380	5/21 (24%)
		leucine-rich repeat	346..368	CDD:275380	5/21 (24%)
		leucine-rich repeat	369..392	CDD:275380	6/22 (27%)
		leucine-rich repeat	417..440	CDD:275380	6/22 (27%)
		leucine-rich repeat	441..486	CDD:275380	13/47 (28%)
		PPP1R42	472..617	CDD:455733	48/146 (33%)
		leucine-rich repeat	487..507	CDD:275380	6/19 (32%)
		leucine-rich repeat	510..532	CDD:275380	11/21 (52%)
		leucine-rich repeat	556..578	CDD:275380	8/21 (38%)
		leucine-rich repeat	603..626	CDD:275380	5/21 (24%)
LRRC8C	XP_006711023.1	Pannexin_like	6..343	CDD:463622
		leucine-rich repeat	451..473	CDD:275378	7/21 (33%)
		leucine-rich repeat	474..497	CDD:275380	6/22 (27%)
		leucine-rich repeat	498..520	CDD:275380	9/21 (43%)
		PPP1R42	<517..627	CDD:455733	40/199 (20%)
		leucine-rich repeat	521..548	CDD:275380	13/90 (14%)
		leucine-rich repeat	549..571	CDD:275380	5/22 (23%)
		leucine-rich repeat	572..595	CDD:275380	6/25 (24%)
		LRR	<587..>777	CDD:443914	61/213 (29%)
		leucine-rich repeat	596..618	CDD:275380	7/43 (16%)
		leucine-rich repeat	619..643	CDD:275380	7/24 (29%)
		leucine-rich repeat	644..666	CDD:275380	6/21 (29%)
		leucine-rich repeat	667..689	CDD:275380	6/21 (29%)
		leucine-rich repeat	713..735	CDD:275380	5/21 (24%)
		leucine-rich repeat	736..757	CDD:275380	7/20 (35%)