DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and PIRL4

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_195272.1	Gene:	PIRL4 / 829699	AraportID:	AT4G35470	Length:	549	Species:	Arabidopsis thaliana

Alignment Length:	476	Identity:	140/476 - (29%)
Similarity:	203/476 - (42%)	Gaps:	100/476 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CFAGGSGTAGAIAGTEELSNANSPANGAGGATGSTGSGQQPTGSNGHSHLHNENNANMPPETRPK 122
            |.|..|.. |:::....|..|.:.|                ..|:..|.|:....|    ..|||
plant   116 CIASPSSN-GSVSSRPPLPPATTTA----------------ARSDSQSSLNFSERA----PVRPK 159

  Fly   123 -MVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVK-ECVHL 185
             ||       ::......||||.....|...|..|       |..:..|::|......| ..:.|
plant   160 DMV-------SRDDSFVTKSKPSSLYSDGFAAPPR-------RPQILDSTLTTGNDGEKLSLIKL 210

  Fly   186 TELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTS----LPESLQNCSQLKVLDLRHNKLAEIPP 246
            ..|...|.|  :...||       ||   :|.||.    ||:||...|.|..|||..|.:..:|.
plant   211 ASLIEVSAK--KATQEI-------NL---QNKLTEQLEWLPDSLGKLSSLTSLDLSENHIVVLPN 263

  Fly   247 VIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLE 311
            .|..|.|||.|.|..|||..:.:.:.:|:||..|:|..|::..|.||...||.|..||:|.|:|.
plant   264 TIGGLSSLTKLDLHSNRIGQLPESIGELLNLVYLNLGSNQLSSLPSAFSRLVRLEELDLSCNNLP 328

  Fly   312 HLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEG 376
            .|||.||:.|:|..||::.|::.:||.|||...||:.|...||:|.::|..:....:::..:|..
plant   329 ILPESIGSLVSLKKLDVETNDIEEIPYSIGGCSSLIELRADYNKLKALPEAIGKITTLEILSVRY 393

  Fly   377 NGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGL 441
            |.|.|||..| :||:.|..:.:|.|:..|.|..                         ...|..|
plant   394 NNIRQLPTTM-SSLASLKELDVSFNELESVPES-------------------------LCFATTL 432

  Fly   442 TKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGN 506
            .|||:..|           :.:||          .||..|.||:.||.|.:|||.::.:|::...
plant   433 VKLNIGNN-----------FADMV----------SLPRSIGNLEMLEELDISNNQIRVLPDSFKM 476

  Fly   507 LRKLRILDLEENRIEVLPHEI 527
            |.|||:...:||.:.:.|.:|
plant   477 LTKLRVFRAQENPLHIPPRDI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	4/21 (19%)
		leucine-rich repeat	185..207	CDD:275380	6/21 (29%)
		LRR_RI	204..401	CDD:238064	76/200 (38%)
		LRR_8	207..264	CDD:290566	24/60 (40%)
		leucine-rich repeat	208..230	CDD:275380	9/25 (36%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	24/57 (42%)
		leucine-rich repeat	254..276	CDD:275380	8/21 (38%)
		leucine-rich repeat	277..299	CDD:275380	8/21 (38%)
		LRR_8	299..356	CDD:290566	26/56 (46%)
		leucine-rich repeat	300..322	CDD:275380	11/21 (52%)
		leucine-rich repeat	323..345	CDD:275380	9/21 (43%)
		LRR_8	344..403	CDD:290566	19/58 (33%)
		leucine-rich repeat	346..368	CDD:275380	6/21 (29%)
		leucine-rich repeat	369..392	CDD:275380	9/22 (41%)
		LRR_RI	<379..566	CDD:238064	40/149 (27%)
		leucine-rich repeat	417..440	CDD:275380	1/22 (5%)
		leucine-rich repeat	441..486	CDD:275380	12/44 (27%)
		LRR_8	463..520	CDD:290566	20/56 (36%)
		leucine-rich repeat	487..507	CDD:275380	7/19 (37%)
		leucine-rich repeat	510..532	CDD:275380	6/18 (33%)
		LRR_8	532..588	CDD:290566
		leucine-rich repeat	556..578	CDD:275380
		leucine-rich repeat	603..626	CDD:275380
PIRL4	NP_195272.1	LRR	194..>471	CDD:227223	107/335 (32%)
		leucine-rich repeat	271..293	CDD:275380	8/21 (38%)
		leucine-rich repeat	294..316	CDD:275380	8/21 (38%)
		leucine-rich repeat	317..339	CDD:275380	11/21 (52%)
		leucine-rich repeat	340..362	CDD:275380	9/21 (43%)
		leucine-rich repeat	363..385	CDD:275380	6/21 (29%)
		leucine-rich repeat	386..408	CDD:275380	9/22 (41%)
		leucine-rich repeat	409..431	CDD:275380	6/46 (13%)
		leucine-rich repeat	432..456	CDD:275380	12/44 (27%)
		leucine-rich repeat	457..479	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3538
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010