DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and PIRL2

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_189281.2	Gene:	PIRL2 / 822257	AraportID:	AT3G26500	Length:	471	Species:	Arabidopsis thaliana

Alignment Length:	611	Identity:	148/611 - (24%)
Similarity:	224/611 - (36%)	Gaps:	197/611 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 HSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLS 168
            |.|   ::|.:.||             |...:.|...|.|:.::.:::..|.:.
plant    16 HQH---DSNLHAPP-------------SMAAQETLLPSFPLLSNPEIMSMLTQS----------- 53

  Fly   169 KSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQL-- 231
                  ||:|:      |:.....|.:|..|..:....:...:|...:||:  ||.....|::
plant    54 ------IPTTI------TQTLFVFNSLGSRPDPLAVSSARFKIAQIMDSLS--PEEAAKESEIYA 104

  Fly   232 ------KVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLR--QLVNLTMLSLRENKIR 288
                  :|.|....||.:....:.|:.|           |.|...||  :.||..:|::.  |..
plant   105 GVVRLDEVHDSYEKKLKDTEEELSRVYS-----------TEVESMLRSGEEVNEKVLAVL--KEA 156

  Fly   289 ELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRY 353
            |.|..:      ..:|:|...|:.:||.....|.|..|:|..|:|..|||:|..||.|
plant   157 ESGGTV------ERIDLSSQELKLIPEAFWKVVGLVYLNLSGNDLTFIPDAISKLKKL------- 208

  Fly   354 NRLSSVPATLKNCKSMDEFNVEGNGITQLPD--GMLASLSGLTTITLSRNQFASYPTGGPAQFTN 416
                            :|.:|..|.:..|||  |||.:|
plant   209 ----------------EELDVSSNSLESLPDSIGMLLNL-------------------------- 231

  Fly   417 VYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDI 481
                     ||                ||:..|.|||||..|....::|||:.:.|.|..||.:|
plant   232 ---------RI----------------LNVNANNLTALPESIAHCRSLVELDASYNNLTSLPTNI 271

  Fly   482 -MNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQT--NQI 543
             ..|||||.|.:..|.|:..|.:|..:..|:.||...|.|..:|:.||.|.:|:.|.|.:  |.:
plant   272 GYGLQNLERLSIQLNKLRYFPGSISEMYNLKYLDAHMNEIHGIPNSIGRLTKLEVLNLSSNFNNL 336

  Fly   544 TMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNI 608
            ..:|.:|..|.||..|.:|.|.:|.:|:....|..||.|.::||| ||
plant   337 MGVPDTITDLTNLRELDLSNNQIQAIPDSFYRLRKLEKLNLDQNP-LE----------------- 383

  Fly   609 DKCPLSTIP-PEIQAGGPSLVLQ-----WLKMHSPYRQMXDVDGV-------WRTVYVGSDCYYQ 660
                   || .|:...|..:|.:     |..:.:..:|...|:..       |  ||.|:.
plant   384 -------IPSQEVATQGAEVVREFMRKRWGDIMAEQQQRIGVEAERHGDENGW--VYWGTS---- 435

  Fly   661 YELQTVNQAPGAGGN-GGGGAAAAGG 685
               ...|...|.... |.|||.:.||
plant   436 ---MVTNLVSGVTHTIGFGGATSDGG 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	3/20 (15%)
		leucine-rich repeat	185..207	CDD:275380	4/21 (19%)
		LRR_RI	204..401	CDD:238064	50/208 (24%)
		LRR_8	207..264	CDD:290566	12/64 (19%)
		leucine-rich repeat	208..230	CDD:275380	5/21 (24%)
		leucine-rich repeat	231..253	CDD:275380	5/29 (17%)
		LRR_8	252..310	CDD:290566	13/59 (22%)
		leucine-rich repeat	254..276	CDD:275380	4/23 (17%)
		leucine-rich repeat	277..299	CDD:275380	4/21 (19%)
		LRR_8	299..356	CDD:290566	18/56 (32%)
		leucine-rich repeat	300..322	CDD:275380	5/21 (24%)
		leucine-rich repeat	323..345	CDD:275380	10/21 (48%)
		LRR_8	344..403	CDD:290566	12/60 (20%)
		leucine-rich repeat	346..368	CDD:275380	1/21 (5%)
		leucine-rich repeat	369..392	CDD:275380	10/24 (42%)
		LRR_RI	<379..566	CDD:238064	57/191 (30%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		leucine-rich repeat	441..486	CDD:275380	18/45 (40%)
		LRR_8	463..520	CDD:290566	22/57 (39%)
		leucine-rich repeat	487..507	CDD:275380	7/19 (37%)
		leucine-rich repeat	510..532	CDD:275380	9/21 (43%)
		LRR_8	532..588	CDD:290566	19/57 (33%)
		leucine-rich repeat	556..578	CDD:275380	7/21 (33%)
		leucine-rich repeat	603..626	CDD:275380	4/23 (17%)
PIRL2	NP_189281.2	leucine-rich repeat	162..184	CDD:275380	5/27 (19%)
		LRR_RI	169..408	CDD:238064	93/337 (28%)
		LRR_8	184..241	CDD:290566	27/130 (21%)
		leucine-rich repeat	185..207	CDD:275380	10/21 (48%)
		leucine-rich repeat	208..230	CDD:275380	10/44 (23%)
		LRR_8	230..288	CDD:290566	27/108 (25%)
		leucine-rich repeat	231..253	CDD:275380	12/72 (17%)
		leucine-rich repeat	254..277	CDD:275380	9/22 (41%)
		leucine-rich repeat	278..300	CDD:275380	7/21 (33%)
		leucine-rich repeat	301..323	CDD:275380	9/21 (43%)
		LRR_8	322..382	CDD:290566	21/60 (35%)
		leucine-rich repeat	324..348	CDD:275380	7/23 (30%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3538
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910