DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sur-8 and LRRK1

DIOPT Version :10

Sequence 1:NP_001262665.1 Gene:Sur-8 / 42093 FlyBaseID:FBgn0038504 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_078928.3 Gene:LRRK1 / 79705 HGNCID:18608 Length:2015 Species:Homo sapiens


Alignment Length:665 Identity:152/665 - (22%)
Similarity:244/665 - (36%) Gaps:196/665 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 ENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQ--DVIKALQRCRDEGIKR-------- 164
            |.:|..|...   |.|:........||:|:...|....:  :.|:|..|..|.|..|        
Human    18 EESAVCPERA---METLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACD 79

  Fly   165 ---LDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPE------------IGCLVSLRNLALN 214
               ..|.|..:..||:...:...:.  ||.|.::.:||.|            .|      :.|:.
Human    80 QCASQLEKGQLLSIPAAYGDLEMVR--YLLSKRLVELPTEPTDDNPAVVAAYFG------HTAVV 136

  Fly   215 ENSLTSL-----PESLQN------CSQ-----LKVLDLRHN--------KLAEIPPV-------- 247
            :..|.||     |:.|.|      |.:     :|:|.|.|.        :..|.|.:        
Human   137 QELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAA 201

  Fly   248 ---------IYRLR------------------------------------SLTTLYLRFNRITAV 267
                     |:.||                                    ..|.|.::::.:...
Human   202 IKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTALRVKWSHLRLP 266

  Fly   268 ADDLRQLVN----LTMLSLRENKIRELGSAI-GALVNLTTLDVSHNHLEHLP----EDIGNCVNL 323
            ..||..|::    :|.|.|..|.:..|.|.| ..|:||..|::|.|||..||    .|...|..|
Human   267 WVDLDWLIDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRL 331

  Fly   324 SALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNC----------------KSMDEF 372
            ..:|:..|:|..:|....:|..|.:|           ...|||                :.:.|.
Human   332 LEIDISSNKLSHLPPGFLHLSKLQKL-----------TASKNCLEKLFEEENATNWIGLRKLQEL 385

  Fly   373 NVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSR 437
            ::..|.:|:||...|.|...|.::.:|||....:|.                      |:     
Human   386 DISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPD----------------------PW----- 423

  Fly   438 AKGLTKLNMKENMLTALPLDIGT-WVN-MVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKI 500
            |..|.......|.|..||..:.. |.| :.:::.:.|||:::|..:..|..|..|.|..|.|..:
Human   424 ACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAAL 488

  Fly   501 -PNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQ-----------ITMLPRSIGHL 553
             |......|:|:.|||..|::.  .:|.||  :.:|:...|.:           :...|..:.. 
Human   489 PPQEKWTCRQLKTLDLSRNQLG--KNEDGL--KTKRIAFFTTRGRQRSGTEAASVLEFPAFLSE- 548

  Fly   554 GNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNIDKCPLSTIPP 618
             :|..|.:::|:|..:|..:..|:||..||:..||||.:||.||....||..|:.:...:|.:|.
Human   549 -SLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPA 612

  Fly   619 EIQAGGPSLVLQWLK 633
            |||..||..:|.:|:
Human   613 EIQKEGPKAMLSYLR 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sur-8NP_001262665.1 leucine-rich repeat 163..184 CDD:275380 5/31 (16%)
LRR 185..535 CDD:443914 100/466 (21%)
leucine-rich repeat 185..207 CDD:275380 7/33 (21%)
leucine-rich repeat 208..230 CDD:275380 8/32 (25%)
leucine-rich repeat 231..253 CDD:275380 9/82 (11%)
leucine-rich repeat 254..276 CDD:275380 5/21 (24%)
leucine-rich repeat 277..299 CDD:275380 8/22 (36%)
leucine-rich repeat 300..322 CDD:275380 10/25 (40%)
leucine-rich repeat 323..345 CDD:275380 6/21 (29%)
leucine-rich repeat 346..368 CDD:275380 5/37 (14%)
leucine-rich repeat 369..392 CDD:275380 7/22 (32%)
leucine-rich repeat 417..440 CDD:275380 2/22 (9%)
leucine-rich repeat 441..486 CDD:275380 12/46 (26%)
PPP1R42 472..617 CDD:455733 45/156 (29%)
leucine-rich repeat 487..507 CDD:275380 6/20 (30%)
leucine-rich repeat 510..532 CDD:275380 8/21 (38%)
leucine-rich repeat 556..578 CDD:275380 6/21 (29%)
leucine-rich repeat 603..626 CDD:275380 8/22 (36%)
LRRK1NP_078928.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..56 6/32 (19%)
ANK 1. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 51..81 6/29 (21%)
ANKYR 58..>218 CDD:440430 34/167 (20%)
ANK 2. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 86..116 7/31 (23%)
ANK 3. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 119..148 5/34 (15%)
ANK 4. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 152..182 7/29 (24%)
ANK repeat 156..186 CDD:293786 5/29 (17%)
ANK repeat 188..218 CDD:293786 5/29 (17%)
ANK 5. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 193..222 3/28 (11%)
LRR <279..>517 CDD:443914 71/279 (25%)
LRR 1. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 279..300 7/20 (35%)
leucine-rich repeat 281..303 CDD:275380 8/21 (38%)
LRR 2. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 303..324 9/20 (45%)
leucine-rich repeat 304..330 CDD:275380 10/25 (40%)
LRR 3. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 330..351 5/20 (25%)
leucine-rich repeat 331..353 CDD:275380 6/21 (29%)
LRR 4. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 353..374 5/31 (16%)
leucine-rich repeat 354..381 CDD:275380 5/37 (14%)
LRR 5. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 381..402 6/20 (30%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
LRR 6. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 405..426 7/47 (15%)
leucine-rich repeat 406..451 CDD:275380 13/71 (18%)
LRR 7. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 427..447 5/19 (26%)
PLN00113 445..>614 CDD:215061 48/174 (28%)
LRR 8. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 451..472 4/20 (20%)
leucine-rich repeat 452..474 CDD:275380 5/21 (24%)
LRR 9. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 474..495 6/20 (30%)
leucine-rich repeat 475..498 CDD:275380 6/22 (27%)
LRR 10. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 498..519 8/24 (33%)
leucine-rich repeat 499..549 CDD:275380 11/55 (20%)
LRR 11. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 549..570 5/20 (25%)
leucine-rich repeat 550..572 CDD:275380 6/21 (29%)
LRR 12. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 572..594 12/21 (57%)
LRR 13. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 596..617 8/20 (40%)
P-loop containing Nucleoside Triphosphate Hydrolases 639..821 CDD:476819
COR 844..1036 CDD:406489
STKc_LRRK1 1248..1523 CDD:270969
WD 1. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1539..1579
WD 2. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1582..1622
WD 3. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1623..1668
WD 4. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1693..1729
WD 5. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1730..1778
WD 6. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1779..1949
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1788..1810
WD40 loop, involved in dimer stabilization. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821 1791..1907
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1841..1899
WD 7. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1951..1987
Blue background indicates that the domain is not in the aligned region.

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