Protein Alignment Sur-8 and erbin

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: XP_004910435.2
• Gene: erbin / 734027
• XenbaseID: XB-GENE-977040
• Length: 1446
• Species: Xenopus tropicalis
• Alignment Length: 526
• Identity: 149/526 - (28%)
• Similarity: 227/526 - (43%)
• Gaps: 128/526 - (24%)

  Fly   137 TTKKSKPIQADQDVIKALQRCR-----DEGIKRLDLSKSSITVIPSTVKECV----HLTELYLYS 192
            |||:        :::..|..||     :|.:..||.|..|:..:|   ||..    .|.||||.:
 Frog     2 TTKR--------NLLVRLVPCRCLRGEEETVTSLDYSHCSLEQVP---KEIFTFEKTLEELYLDA 55

  Fly   193 NKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTL 257
            |:|.:||.::....||..|:|.:|.||.||.|:.|...|:.||:..|.:.|.|..|...:.||.:
 Frog    56 NQIEELPKQLFNCQSLHKLSLPDNDLTILPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120

  Fly   258 YLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVN 322
            ....|.|:.:.|...||:|||.|.|.:                       ..|:.||.:.|....
 Frog   121 EASVNPISKLPDGFSQLLNLTQLYLND-----------------------AFLDFLPANFGRLTK 162

  Fly   323 LSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGML 387
            |..|:|:.|:|..:|.::..|..|.||.:..|..:.||..|:....:.||.::||.:|.:| |.|
 Frog   163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDGNKLTYIP-GFL 226

  Fly   388 ASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLT 452
            .:|..||.:.:|:|                   |:|
 Frog   227 GNLKQLTYLDVSKN-------------------NIE----------------------------- 243

  Fly   453 ALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRKLRILDLEE 517
                       |||            |.|...::|:.|:||:|.::::|.:||.|:||..|.::|
 Frog   244 -----------MVE------------DGISGCESLQDLLLSSNAIQQLPESIGALKKLTTLKVDE 285

  Fly   518 NRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENL 582
            |::..||..||.|..::.|....|:|..||.|||||..:...:...|.|..||.|||:.:|...|
 Frog   286 NQLMYLPDSIGGLTAIEDLDCSFNEIEALPSSIGHLIQIRTFAADHNFLTQLPPEIGTWKSATVL 350

  Fly   583 YINQNPGLEKLPFELALCQNLKYLNIDKCPLSTIP---PEIQAGGPSLVLQWL-----KMHSPYR 639
            :::.|. ||.||.|:...|.||.:|:....|..:|   ..:|    .|...||     |...|.:
 Frog   351 FLHSNK-LESLPEEMGDMQKLKVINLSDNRLRNLPFSFTRLQ----QLTAMWLSDNQSKPLIPLQ 410

  Fly   640 QMXDVD 645
            :..|.|
 Frog   411 KETDQD 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/24 (29%)
		LRR	185..535	CDD:443914	96/349 (28%)
		leucine-rich repeat	185..207	CDD:275380	9/21 (43%)
		leucine-rich repeat	208..230	CDD:275380	10/21 (48%)
		leucine-rich repeat	231..253	CDD:275380	7/21 (33%)
		leucine-rich repeat	254..276	CDD:275380	7/21 (33%)
		leucine-rich repeat	277..299	CDD:275380	4/21 (19%)
		leucine-rich repeat	300..322	CDD:275380	4/21 (19%)
		leucine-rich repeat	323..345	CDD:275380	7/21 (33%)
		leucine-rich repeat	346..368	CDD:275380	7/21 (33%)
		leucine-rich repeat	369..392	CDD:275380	9/22 (41%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		leucine-rich repeat	441..486	CDD:275380	5/44 (11%)
		PPP1R42	472..617	CDD:455733	51/144 (35%)
		leucine-rich repeat	487..507	CDD:275380	8/19 (42%)
		leucine-rich repeat	510..532	CDD:275380	9/21 (43%)
		leucine-rich repeat	556..578	CDD:275380	7/21 (33%)
		leucine-rich repeat	603..626	CDD:275380	6/25 (24%)
erbin	XP_004910435.2	leucine-rich repeat	24..47	CDD:275380	7/25 (28%)
		leucine-rich repeat	48..70	CDD:275380	9/21 (43%)
		LRR	67..424	CDD:443914	126/450 (28%)
		leucine-rich repeat	71..93	CDD:275380	10/21 (48%)
		leucine-rich repeat	94..139	CDD:275380	14/44 (32%)
		leucine-rich repeat	117..131	CDD:275378	4/13 (31%)
		leucine-rich repeat	140..162	CDD:275380	8/44 (18%)
		leucine-rich repeat	163..185	CDD:275380	7/21 (33%)
		leucine-rich repeat	186..208	CDD:275380	7/21 (33%)
		leucine-rich repeat	209..231	CDD:275380	9/22 (41%)
		leucine-rich repeat	232..254	CDD:275380	11/92 (12%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..300	CDD:275380	8/20 (40%)
		leucine-rich repeat	301..336	CDD:275380	12/34 (35%)
		leucine-rich repeat	337..369	CDD:275380	13/32 (41%)
		leucine-rich repeat	370..390	CDD:275380	5/19 (26%)
		PDZ_densin_erbin-like	1356..1442	CDD:467231