DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur-8 and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001262665.1	Gene:	Sur-8 / 42093	FlyBaseID:	FBgn0038504	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	144/521 - (27%)
Similarity:	226/521 - (43%)	Gaps:	104/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 IKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQ 226
            :|.|:||.:.:...||.|.....|.||.:..|.:.::|..:|.:.:|:...|:.|.|.|||..|:
  Rat   656 LKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNALREVPAAVGAMQNLQTFLLDGNFLQSLPAELE 720

  Fly   227 NCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFN-----RITA-------------------- 266
            |..||..|.|..|:..:||.|:.:|.::..|.:..|     |:.|
  Rat   721 NMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCMETLRLQALRRMPHIKHVDLRLNILRKL 785

  Fly   267 VADDLRQLVNLTMLSLRENKIRELGSAI-------------------------------GALVN- 299
            :.|::..|.::|.|.||:||:.:|.:.|                               ..||.
  Rat   786 ITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNICGYFLKALYASSNELVQL 850

  Fly   300 --------LTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRL 356
                    |:.:|||.|.||.:||.:.....|..||:.||::.::|..:....||.:|...:|||
  Rat   851 DVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNRL 915

  Fly   357 SSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSIN 421
            :.:|..|:. .|::..:|:.|.|.:||..:|.....|..:..|.|:..:.|   ||      :::
  Rat   916 ARLPERLER-TSVEVLDVQHNQIIELPPNLLMKADSLRFLNASANKLETLP---PA------TLS 970

  Fly   422 LEHNRIDKIPYGIFSRAKGLTKLNMKENMLT--ALPLDIGTWVNMVELNLATNALQKLPDDIM-N 483
            .|.:.|             |.:|.:..|.||  .:||..| ...:..|::|.|.||..|...| .
  Rat   971 EETSSI-------------LQELYLTNNSLTDKCVPLLTG-HPRLKILHMAYNRLQSFPASKMAK 1021

  Fly   484 LQNLEILILSNNMLKKIPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPR 548
            |:.||.:.:|.|.||.||.||.|.|::..:....|.|||.| |:..|.|::    .|.....|.|
  Rat  1022 LEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEVK----STEGNGSLSR 1081

  Fly   549 SIGHLGNLTH----LSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNID 609
            | ..|..|.|    ||.:|.:...|||.:.  ..|:.|.:..||.|......|.|..|::...||
  Rat  1082 S-SFLFPLFHQCVDLSCNELSEITLPENLP--PKLQELDLTGNPRLALDHKSLELLNNIRCFKID 1143

  Fly   610 K 610
            :
  Rat  1144 Q 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	7/20 (35%)
		leucine-rich repeat	185..207	CDD:275380	6/21 (29%)
		LRR_RI	204..401	CDD:238064	66/261 (25%)
		LRR_8	207..264	CDD:290566	20/61 (33%)
		leucine-rich repeat	208..230	CDD:275380	9/21 (43%)
		leucine-rich repeat	231..253	CDD:275380	8/21 (38%)
		LRR_8	252..310	CDD:290566	21/122 (17%)
		leucine-rich repeat	254..276	CDD:275380	6/46 (13%)
		leucine-rich repeat	277..299	CDD:275380	9/52 (17%)
		LRR_8	299..356	CDD:290566	19/65 (29%)
		leucine-rich repeat	300..322	CDD:275380	9/21 (43%)
		leucine-rich repeat	323..345	CDD:275380	6/21 (29%)
		LRR_8	344..403	CDD:290566	18/58 (31%)
		leucine-rich repeat	346..368	CDD:275380	7/21 (33%)
		leucine-rich repeat	369..392	CDD:275380	6/22 (27%)
		LRR_RI	<379..566	CDD:238064	58/193 (30%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		leucine-rich repeat	441..486	CDD:275380	16/47 (34%)
		LRR_8	463..520	CDD:290566	21/57 (37%)
		leucine-rich repeat	487..507	CDD:275380	10/19 (53%)
		leucine-rich repeat	510..532	CDD:275380	7/21 (33%)
		LRR_8	532..588	CDD:290566	16/59 (27%)
		leucine-rich repeat	556..578	CDD:275380	8/25 (32%)
		leucine-rich repeat	603..626	CDD:275380	2/8 (25%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021
		RA_PHLPP1	<424..491	CDD:340760
		PH_PHLPP-like	498..594	CDD:270131
		PLN00113	602..>1109	CDD:215061	134/482 (28%)
		leucine-rich repeat	604..624	CDD:275380
		leucine-rich repeat	625..655	CDD:275380
		leucine-rich repeat	679..701	CDD:275380	6/21 (29%)
		leucine-rich repeat	702..724	CDD:275380	9/21 (43%)
		leucine-rich repeat	725..771	CDD:275380	12/45 (27%)
		leucine-rich repeat	772..795	CDD:275380	2/22 (9%)
		leucine-rich repeat	796..816	CDD:275380	8/19 (42%)
		leucine-rich repeat	817..858	CDD:275380	2/40 (5%)
		leucine-rich repeat	859..881	CDD:275380	9/21 (43%)
		leucine-rich repeat	882..904	CDD:275380	6/21 (29%)
		leucine-rich repeat	905..926	CDD:275380	7/21 (33%)
		leucine-rich repeat	927..950	CDD:275380	6/22 (27%)
		leucine-rich repeat	951..974	CDD:275380	7/31 (23%)
		leucine-rich repeat	977..1000	CDD:275380	8/23 (35%)
		leucine-rich repeat	1001..1024	CDD:275380	8/22 (36%)
		leucine-rich repeat	1067..1112	CDD:275380	15/51 (29%)
		PP2Cc	1151..1403	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10213
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910