Protein Alignment Sur-8 and LRCH2

DIOPT Version :10

• Sequence 1: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_065922.3
• Gene: LRCH2 / 57631
• HGNCID: 29292
• Length: 765
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 111/470 - (23%)
• Similarity: 187/470 - (39%)
• Gaps: 113/470 - (24%)

  Fly    32 AEGGGGSGNSGGGGKTSNGSAEAPTLCFAGGSGTAGAIAGTEELSNANSPANGAGGATGSTGSG- 95
            |...||.|||||||....||        :||.||||               .|.|||.|..|.|
Human     2 AASQGGGGNSGGGGCGGGGS--------SGGCGTAG---------------GGGGGAGGGGGGGG 43

  Fly    96 -------QQPTGSNGHSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKA 153
                   ..||       |..:...|.||         .:|.|.:|:.|.:         .:.:|
Human    44 GTLVVPIPVPT-------LFGQPFPNGPP---------WNPGSLQPQHTVR---------SLDRA 83

  Fly   154 LQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSL 218
            |:.....||  |.||...:...|.:..:....|:..|..|:..::|.::.....|..|.|..|.:
Human    84 LEEAGSSGI--LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCI 146

  Fly   219 TSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLR 283
            .::||:::|...|..|::..|.|:.:|..::.|                        .|.:|.:.
Human   147 KTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL------------------------PLKVLVVS 187

  Fly   284 ENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVR 348
            .||:..:...||.|.:|..||:|.|.::.||:.:|...:|..|:::.|.|..:||.:|:| .||:
Human   188 NNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVK 251

  Fly   349 LGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQ 413
            |....|:::.:|...:....:....::.|.: |:|...:. |.|...|               .:
Human   252 LDFSCNKVTEIPVCYRKLHHLQVIILDNNPL-QVPPAQIC-LKGKVHI---------------FK 299

  Fly   414 FTNVYSINLEHNRIDKIP--YGIFSRAKGLTKLNMKENMLTALP-----LDIGTWVNMVELNLAT 471
            :.|:.:.    .|:||.|  ..:.|.:|.:....:.::|....|     .|.|...:..|..|:|
Human   300 YLNIQAC----CRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLST 360

  Fly   472 NALQKLPDDIMNLQN 486
            .  :...||.::|.:
Human   361 T--EPSDDDTVSLHS 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380	4/20 (20%)
		LRR	185..535	CDD:443914	68/309 (22%)
		leucine-rich repeat	185..207	CDD:275380	4/21 (19%)
		leucine-rich repeat	208..230	CDD:275380	7/21 (33%)
		leucine-rich repeat	231..253	CDD:275380	6/21 (29%)
		leucine-rich repeat	254..276	CDD:275380	0/21 (0%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		leucine-rich repeat	300..322	CDD:275380	8/21 (38%)
		leucine-rich repeat	323..345	CDD:275380	8/21 (38%)
		leucine-rich repeat	346..368	CDD:275380	5/21 (24%)
		leucine-rich repeat	369..392	CDD:275380	4/22 (18%)
		leucine-rich repeat	417..440	CDD:275380	5/24 (21%)
		leucine-rich repeat	441..486	CDD:275380	10/49 (20%)
		PPP1R42	472..617	CDD:455733	3/15 (20%)
		leucine-rich repeat	487..507	CDD:275380	111/470 (24%)
		leucine-rich repeat	510..532	CDD:275380
		leucine-rich repeat	556..578	CDD:275380
		leucine-rich repeat	603..626	CDD:275380
LRCH2	NP_065922.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		23/59 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..76		7/29 (24%)
		LRR 1	89..110		6/22 (27%)
		leucine-rich repeat	92..112	CDD:275380	5/21 (24%)
		LRR	<108..>282	CDD:443914	46/198 (23%)
		LRR 2	112..133		4/20 (20%)
		leucine-rich repeat	113..135	CDD:275380	4/21 (19%)
		LRR 3	135..156		6/20 (30%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		LRR 4	158..179		5/20 (25%)
		leucine-rich repeat	159..174	CDD:275380	4/14 (29%)
		LRR 5	180..201		6/20 (30%)
		leucine-rich repeat	181..203	CDD:275380	7/21 (33%)
		LRR 6	203..224		8/20 (40%)
		leucine-rich repeat	204..226	CDD:275380	8/21 (38%)
		LRR 7	226..248		8/22 (36%)
		leucine-rich repeat	227..247	CDD:275380	7/19 (37%)
		leucine-rich repeat	249..271	CDD:275380	5/21 (24%)
		LRR 8	249..269		5/19 (26%)
		LRR 9	271..292		3/22 (14%)
		leucine-rich repeat	272..290	CDD:275380	3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..401		12/60 (20%)
		DUF5401	<434..539	CDD:375164
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..552
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..628
		CH_LRCH2	643..753	CDD:409120